cGMP Signaling in Cardiovascular Diseases: Linking Genotype and Phenotype

被引：17
作者：
Dang, Tan An [1 ]
Schunkert, Heribert [1 ,2 ]
Kessler, Thorsten [1 ,2 ]
机构：
[1] Tech Univ Munich, Klin Herz & Kreislauferkrankungen, Deutsch Herzzentrum Munchen, Lazarettstr 36, D-80636 Munich, Germany
[2] Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partnersite Munich Heart Alliance, Munich, Germany
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2020年 / 75卷 / 06期
关键词：
cardiovascular diseases; coronary artery disease; myocardial infarction; genetics; genome-wide association studies; cGMP; NITRIC-OXIDE SYNTHASE; SOLUBLE GUANYLATE-CYCLASE; GENOME-WIDE ASSOCIATION; CYCLIC ADENINE RIBONUCLEOTIDE; CHRONIC HEART-FAILURE; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; PLATELET-AGGREGATION; PULMONARY-HYPERTENSION; PHOSPHOPROTEIN VASP;
D O I：
10.1097/FJC.0000000000000744
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cyclic guanosine 3 ',5 '-monophosphate (cGMP) is the key second messenger molecule in nitric oxide signaling. Its rapid generation and fate, but also its role in mediating acute cellular functions has been extensively studied. In the past years, genetic studies suggested an important role for cGMP in affecting the risk of chronic cardiovascular diseases, for example, coronary artery disease and myocardial infarction. Here, we review the role of cGMP in atherosclerosis and other cardiovascular diseases and discuss recent genetic findings and identified mechanisms. Finally, we highlight open questions and promising research topics.
引用
收藏
页码：516 / 525
页数：10
相关论文
共 126 条
  • [1] Abrams D, 2000, Heart, V84, pE4, DOI 10.1136/heart.84.2.e4
  • [2] Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidiseds GC
    Ahrens, Ingo
    Habersberger, Jonathon
    Baumlin, Nadege
    Qian, Hongwei
    Smith, Belinda K.
    Stasch, Johannes-Peter
    Bode, Christoph
    Schmidt, Harald H. H. W.
    Peter, Karlheinz
    [J]. ATHEROSCLEROSIS, 2011, 218 (02) : 431 - 434
  • [3] Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
    Aicher, A
    Heeschen, C
    Mildner-Rihm, C
    Urbich, C
    Ihling, C
    Technau-Ihling, K
    Zeiher, AM
    Dimmeler, S
    [J]. NATURE MEDICINE, 2003, 9 (11) : 1370 - 1376
  • [4] iNOS-mediated nitric oxide production and its regulation
    Aktan, F
    [J]. LIFE SCIENCES, 2004, 75 (06) : 639 - 653
  • [5] Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Iβ
    Ammendola, A
    Geiselhöringer, A
    Hofmann, F
    Schlossmann, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) : 24153 - 24159
  • [6] [Anonymous], 1989, NEW ENGL J MED, V321, P129, DOI [DOI 10.1056/NEJM198907203210301, 10.1056/NEJM198907203210301.]
  • [7] IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
    Antl, Melanie
    von Bruehl, Marie-Luise
    Eiglsperger, Christina
    Werner, Matthias
    Konrad, Ildiko
    Kocher, Thomas
    Wilm, Matthias
    Hofmann, Franz
    Massberg, Steffen
    Schlossmann, Jens
    [J]. BLOOD, 2007, 109 (02) : 552 - 559
  • [8] The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function
    Aszódi, A
    Pfeifer, A
    Ahmad, M
    Glauner, M
    Zhou, XH
    Ny, L
    Andersson, KE
    Kehrel, B
    Offermanns, S
    Fässler, R
    [J]. EMBO JOURNAL, 1999, 18 (01) : 37 - 48
  • [9] Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000659, 10.1161/CIR.0000000000000746]
  • [10] NO-SYNTHASE ACTIVITY IN PATIENTS WITH CORONARY HEART DISEASE ASSOCIATED WITH HYPERTENSION OF DIFFERENT AGE GROUPS
    Besedina, Anna
    [J]. JOURNAL OF MEDICAL BIOCHEMISTRY, 2016, 35 (01) : 43 - 49
12345678910