Interleukin-17 levels correlate with poor prognosis and vascular endothelial growth factor concentration in the serum of patients with non-small cell lung cancer

被引：39
作者：
Pan, Bo [1 ]
Che, Dehai [1 ]
Cao, Jingyan [1 ]
Shen, Jing [1 ]
Jin, Shi [1 ]
Zhou, Yongxu [2 ]
Liu, Fang [1 ]
Gu, Kuo [1 ]
Man, Yingchun [3 ]
Shang, Lihua [1 ]
Yu, Yan [1 ]
机构：
[1] Harbin Med Univ, Canc Hosp, Dept Med Oncol, Harbin 150081, Heilongjiang Pr, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, Harbin 150081, Heilongjiang Pr, Peoples R China
[3] Second Hosp Heilongjiang Prov, Gen Hosp Heilongjiang Prov Reclamat Headquarter, Dept Med Oncol, Harbin, Peoples R China
来源：
BIOMARKERS | 2015年 / 20卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Angiogenesis; IL-17; non-small cell lung cancer; prognosis; VEGF; TUMOR ANGIOGENESIS; T-CELLS; HEPATOCELLULAR-CARCINOMA; PROMOTES ANGIOGENESIS; COLORECTAL-CARCINOMA; MULTIPLE-MYELOMA; VEGF PRODUCTION; GASTRIC-CANCER; BREAST-CANCER; IL-17;
D O I：
10.3109/1354750X.2015.1068853
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: The aim of this study was to explore the clinical role of serum interleukin-17 in patients with non-small-cell lung cancer (NSCLC). Materials and method: IL-17 expression and microvessel density (MVD) were measured via immunohistochemistry in 58 NSCLC tissues. Serum IL-17 and VEGF levels in NSCLC patients (n = 43) and healthy controls (n = 37) were analyzed via enzyme-linked immunosorbent assay. Results: Serum IL-17 was elevated and the levels positively correlated with VEGF concentration in NSCLC patients. Multivariate analyses revealed that serum IL-17 levels were an independent prognostic factor in NSCLC. Conclusion: IL-17 may play a role in NSCLC progression by promoting angiogenesis.
引用
收藏
页码：232 / 239
页数：8
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