Interleukin-17 levels correlate with poor prognosis and vascular endothelial growth factor concentration in the serum of patients with non-small cell lung cancer

被引：40

作者：

Pan, Bo ^{[1
]}

Che, Dehai ^{[1
]}

Cao, Jingyan ^{[1
]}

Shen, Jing ^{[1
]}

Jin, Shi ^{[1
]}

Zhou, Yongxu ^{[2
]}

Liu, Fang ^{[1
]}

Gu, Kuo ^{[1
]}

Man, Yingchun ^{[3
]}

Shang, Lihua ^{[1
]}

Yu, Yan ^{[1
]}

机构：

[1] Harbin Med Univ, Canc Hosp, Dept Med Oncol, Harbin 150081, Heilongjiang Pr, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, Harbin 150081, Heilongjiang Pr, Peoples R China

[3] Second Hosp Heilongjiang Prov, Gen Hosp Heilongjiang Prov Reclamat Headquarter, Dept Med Oncol, Harbin, Peoples R China

来源：

BIOMARKERS | 2015年 / 20卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Angiogenesis; IL-17; non-small cell lung cancer; prognosis; VEGF; TUMOR ANGIOGENESIS; T-CELLS; HEPATOCELLULAR-CARCINOMA; PROMOTES ANGIOGENESIS; COLORECTAL-CARCINOMA; MULTIPLE-MYELOMA; VEGF PRODUCTION; GASTRIC-CANCER; BREAST-CANCER; IL-17;

D O I：

10.3109/1354750X.2015.1068853

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: The aim of this study was to explore the clinical role of serum interleukin-17 in patients with non-small-cell lung cancer (NSCLC). Materials and method: IL-17 expression and microvessel density (MVD) were measured via immunohistochemistry in 58 NSCLC tissues. Serum IL-17 and VEGF levels in NSCLC patients (n = 43) and healthy controls (n = 37) were analyzed via enzyme-linked immunosorbent assay. Results: Serum IL-17 was elevated and the levels positively correlated with VEGF concentration in NSCLC patients. Multivariate analyses revealed that serum IL-17 levels were an independent prognostic factor in NSCLC. Conclusion: IL-17 may play a role in NSCLC progression by promoting angiogenesis.

引用

页码：232 / 239

页数：8

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