Zinc protects renal function during cadmium intoxication in the rat

被引:83
作者
Jacquillet, G
Barbier, O
Cougnon, M
Tauc, M
Namorado, MC
Martin, D
Reyes, JL
Poujeol, P
机构
[1] Univ Nice, CNRS, UMR 6548, F-06108 Nice, France
[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Fisiol & Biofis, Mexico City 07000, DF, Mexico
关键词
heavy metals; kidney; protective treatment; tight junction;
D O I
10.1152/ajprenal.00366.2004
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Zinc protects renal function during cadmium intoxication in the rat. Am J Physiol Renal Physiol 290: F127-F137, 2006. First published June 7, 2005; doi:10.1152/ajprenal.00366.2004.- This study investigates the effect in the rat of chronic CdCl2 intoxication (500 mu g Cd2+/kg, daily ip injection for 5 days) on renal function and the changes in tight junction proteins claudin-2, claudin-3, and claudin-5 present in rat kidney. We also studied the effect of coadministration of ZnCl2 (500 mu g Zn2+/ kg) during chronic CdCl2 intoxication. Our results indicate that 1) most of the filtered Cd2+ is reabsorbed within the kidney; 2) chronic Cd2+ intoxication can induce a change in renal handling of ions without altering glomerular filtration rate; 3) a delayed nephropathy, showing Fanconi-like features, appears more than 5 days after the end of CdCl2 exposure; 4) epithelial integrity is altered by chronic Cd2+ intoxication affecting the expression and localization of claudin tight junction proteins; and 5) cotreatment with Zn2+ protects against the renal toxic effects of Cd2+, preventing altered claudin expression and inhibiting apoptosis. In conclusion, these results show that Cd2+ toxicity and cellular toxic mechanisms are complex, probably affecting both membrane transporters and tight junction proteins. Finally, Zn2+ supplementation may provide a basis for future treatments.
引用
收藏
页码:F127 / F137
页数:11
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