Gaucher disease: successful treatment of myoclonic status epilepticus with levetiracetam

被引：6

作者：

Vaca, Guadalupe Fernandez-Baca ^{[3
]}

Lenz, Timothy ^{[2
]}

Knight, Elia M. Pestana ^{[1
]}

Tuxhorn, Ingrid

机构：

[1] Rainbow Babies & Childrens Hosp, Dept Pediat, CWRU, Div Pediat Epilepsy, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland, Case Med Ctr, Dept Emergency Med, Cleveland, OH 44106 USA

[3] Univ Hosp Cleveland, Case Med Ctr, Neurol Inst, Epilepsy Ctr, Cleveland, OH 44106 USA

来源：

EPILEPTIC DISORDERS | 2012年 / 14卷 / 02期

关键词：

Gaucher disease; myoclonic status epilepticus; progressive myoclonus epilepsy; levetiracetam; myoclonic seizures; EEG; INTRAVENOUS LEVETIRACETAM; EPILEPSY; SEIZURES; CHILDREN;

D O I：

10.1684/epd.2012.0501

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present the first reported case of a rapid clinical and electroencephalographic response to intravenous levetiracetam infusion of myoclonic status epilepticus in a patient with progressive myoclonus epilepsy due to Gaucher disease. Under continuous video-EEG monitoring, the clinical myoclonic status and the electrographic ictal discharges resolved within 10 minutes after the infusion was initiated. The patient tolerated the treatment well without any reported side effects. This case suggests that levetiracetam may be a safe, effective, and well tolerated intravenous drug in patients with metabolic myoclonic status epilepticus such as Gaucher disease.

引用

页码：155 / 158

页数：4

共 14 条

[1] Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures [J].

Abend, Nicholas S. ;

Monk, Heather M. ;

Licht, Daniel J. ;

Dlugos, Dennis J. .

PEDIATRIC CRITICAL CARE MEDICINE, 2009, 10 (04) :505-510

[2] The use of levetiracetam in a child with nonconvulsive status epilepticus [J].

Alehan, Fuesun ;

Ozcay, Figen ;

Haberal, Mehmet .

JOURNAL OF CHILD NEUROLOGY, 2008, 23 (03) :331-333

[3] METABOLISM OF GLUCOCEREBROSIDES .2. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHERS DISEASE [J].

BRADY, RO ;

KANFER, JN ;

SHAPIRO, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1965, 18 (02) :221-&

[4]

Frei KP, 2002, ADV NEUROL, V89, P41

[5]

Genton P, 2000, EPILEPTIC DISORD, V2, P209

[6] Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures [J].

Glauser, T. A. ;

Ayala, R. ;

Elterman, R. D. ;

Mitchell, W. G. ;

Van Orman, C. B. ;

Gauer, L. J. ;

Lu, Z. .

NEUROLOGY, 2006, 66 (11) :1654-1660

[7] Intravenous levetiracetam in children with epilepsy [J].

Goraya, Jatinder S. ;

Khurana, Divya S. ;

Valencia, Ignacio ;

Melvin, Joseph J. ;

Cruz, Marcos ;

Legido, Agustin ;

Kothare, Sanjeev V. .

PEDIATRIC NEUROLOGY, 2008, 38 (03) :177-180

[8] Levetiracetam: A novel antiepileptic drug [J].

Hovinga, CA .

PHARMACOTHERAPY, 2001, 21 (11) :1375-1388

[9] Clinical picture of EPM1-Unverricht-Lundborg disease [J].

Kalviainen, Reetta ;

Khyuppenen, Jelena ;

Koskenkorva, Paivi ;

Eriksson, Kai ;

Vanninen, Ritva ;

Mervaala, Esa .

EPILEPSIA, 2008, 49 (04) :549-556

[10] Antimyoclonic effect of levetiracetam in MERRY syndrome [J].

Mancuso, M ;

Galli, R ;

Pizzanelli, C ;

Filosto, M ;

Siciliano, G ;

Murri, L .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2006, 243 (1-2) :97-99

← 1 2 →