Diagnostic modalities for distant metastasis in head and neck squamous cell carcinoma: Are we changing life expectancy?

被引:38
|
作者
Spector, Matthew E. [1 ]
Chinn, Steven B. [1 ]
Rosko, Andrew J. [1 ]
Worden, Francis P. [2 ]
Ward, P. Daniel [1 ]
Divi, Vasu [1 ]
McLean, Scott A. [1 ]
Moyer, Jeffrey S. [1 ]
Prince, Mark E. P. [1 ]
Wolf, Gregory T. [1 ]
Chepeha, Douglas B. [1 ]
Bradford, Carol R. [1 ]
机构
[1] Univ Michigan Hlth Syst, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI USA
[2] Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI USA
来源
LARYNGOSCOPE | 2012年 / 122卷 / 07期
基金
美国国家卫生研究院;
关键词
Distant metastasis; survival; head and neck cancer; positron emission tomography scan; POSITRON-EMISSION-TOMOGRAPHY; RECURRENT HEAD; ONCOLOGY-GROUP; FDG PET; CANCER; CISPLATIN; FLUOROURACIL; CHEMOTHERAPY;
D O I
10.1002/lary.23264
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objectives/Hypothesis: To determine if the various imaging modalities for distant metastasis (DM) diagnosis alters life expectancy in head and neck squamous cell carcinoma (HNSCC). Study Design: Retrospective. Methods: One hundred seventy patients (mean age, 59.1 years; male:female, 135:35) with HNSCC who developed DM were reviewed. The main outcome measures were the method of DM diagnosis and time from DM diagnosis to death while controlling for clinical parameters (age, gender, tobacco status, primary tumor site, initial TNM classification, number and site of DM, administration of palliative chemotherapy). Results: Tumor subsites were: 40 oral cavity, 75 oropharynx, 36 larynx, 10 hypopharynx, one nasopharynx, and eight unknown primary. Of the patients, 16.5% (28/170) had distant metastasis at presentation; the remaining 142 patients were diagnosed with DM at a median of 324 days from diagnosis. Although patients diagnosed with DM by positron-emission tomography (PET) scan were more likely to have multiple DM sites (P = .0001), there were no differences in life expectancy in patients who were diagnosed with or without PET scan (median, 185 vs. 165 days, P = .833). There were no differences in life expectancy based on age, gender, site of primary tumor, or number/site of DM. The use of palliative chemotherapy resulted in a significantly longer life expectancy (median, 285 vs. 70 days; P = .001). Conclusions: Although a PET scan is more likely to diagnose multiple DM sites, there was no difference in life expectancy based on imaging modality. Patients who are symptomatic from their distant metastasis have a worse life expectancy, and palliative chemotherapy was able to increase life expectancy, even in patients who were symptomatic from the distant metastasis.
引用
收藏
页码:1507 / 1511
页数:5
相关论文
共 50 条
  • [21] Intracardiac metastasis from head and neck squamous cell carcinoma
    Abu Khalaf, Suha
    Riaz, Talha
    Mansour, Abdallah
    Doll, Donald
    BMJ CASE REPORTS, 2020, 13 (06)
  • [22] Molecular mediators of metastasis in head and neck squamous cell carcinoma
    Howell, GMS
    Grandis, JR
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2005, 27 (08): : 710 - 717
  • [23] Gene Expression Signature for Distant Metastasis in Loco-regionally Advanced Head and Neck Squamous Cell Carcinoma
    Mo, A.
    Hochfelder, C.
    Berlot, A.
    Prystowsky, M. B.
    Smith, R.
    Schlecht, N. F.
    Schiff, B.
    Mehta, V.
    Rosenblatt, G.
    Belbin, T. J.
    Harris, T. M.
    Childs, G.
    Kawachi, N.
    Kabarriti, R.
    Garg, M. K.
    Guha, C.
    Ow, T.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2020, 108 (03): : S14 - S15
  • [24] Diagnostic and prognostic biomarkers in head and neck squamous cell carcinoma
    Lehnerdt, G.
    Hoffmann, T. K.
    Mattheis, S.
    Brandau, S.
    Zeidler, R.
    Lang, S.
    HNO, 2010, 58 (07) : 713 - 725
  • [25] Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: Metastasis or second primary?
    Geurts, TW
    Nederlof, PM
    van den Brekel, MWM
    van't Veer, LJ
    de Jong, D
    Hart, AAM
    van Zandwijk, N
    Klomp, H
    Balm, AJM
    van Velthuysen, MLF
    CLINICAL CANCER RESEARCH, 2005, 11 (18) : 6608 - 6614
  • [27] Modern management of distant metastases from head and neck squamous cell carcinoma
    Bradley, Patrick
    Montenegro, Claudia
    Piazza, Cesare
    CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY, 2025, 33 (02): : 115 - 122
  • [28] Treatment Strategy for Distant Synchronous Metastatic Head and Neck Squamous Cell Carcinoma
    Tang, Eliane
    Lahmi, Lucien
    Meillan, Nicolas
    Pietta, Gianandrea
    Albert, Sebastien
    Maingon, Philippe
    CURRENT ONCOLOGY REPORTS, 2019, 21 (11)
  • [29] Treatment Strategy for Distant Synchronous Metastatic Head and Neck Squamous Cell Carcinoma
    Eliane Tang
    Lucien Lahmi
    Nicolas Meillan
    Gianandrea Pietta
    Sébastien Albert
    Philippe Maingon
    Current Oncology Reports, 2019, 21
  • [30] Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma
    Braakhuis, B. J. M.
    Senft, A.
    de Bree, R.
    de Vries, J.
    Ylstra, B.
    Cloos, J.
    Kuik, D. J.
    Leemans, C. R.
    Brakenhoff, R. H.
    JOURNAL OF CLINICAL PATHOLOGY, 2006, 59 (12) : 1254 - 1260