Determination of the biodistribution and dosimetry of 123I-FP-CIT in male patients with suspected Parkinsonism or Lewy body dementia using planar and combined planar and SPECT/CT imaging

被引：8
|
作者：
Sydoff, Marie [1 ]
Lizana, Helena [2 ]
Mattsson, Soren [1 ]
Stabin, Michael G. [3 ]
Leide-Svegborn, Sigrid [1 ]
机构：
[1] Lund Univ, Skane Univ Hosp Malmo, Dept Clin Physiol & Nucl Med, SE-20502 Malmo, Sweden
[2] Umea Univ, Dept Radiat Sci, SE-90187 Umea, Sweden
[3] Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN 37235 USA
来源：
APPLIED RADIATION AND ISOTOPES | 2013年 / 82卷
关键词：
Biokinetics; Dosimetry; I-123-FP-CIT; Lewy body dementia; Parkinson's disease; STRIATAL DOPAMINE TRANSPORTERS; SCINTILLATION CAMERA IMAGES; GAMMA-CAMERA; DOUBLE-BLIND; QUANTIFICATION; DISEASE; ACCURACY; CT; OLINDA/EXM; CROSSOVER;
D O I：
10.1016/j.apradiso.2013.09.006
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this study, I-123-FP-CIT biodistribution and dosimetry was determined in 10 adult male patients using planar gamma camera imaging alone or in combination with single photon emission computed tomography /X-ray computed tomography (SPECT/CT) imaging. Dosimetric assessment using planar plus SPECT/CT imaging resulted in significantly different estimates of organ-absorbed doses compared to estimates based on planar imaging alone. We conclude that the use of complementary SPECT/CT measurements in biodistribution studies is valuable for determining the organ doses more accurately. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：300 / 307
页数：8
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