Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors

被引：6

作者：

Wong, Jessica H. ^{[1
]}

Sahni, Urvashi ^{[1
]}

Li, Yanhong ^{[1
]}

Chen, Xi ^{[1
]}

Gervay-Hague, Jacquelyn ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 01期

关键词：

N-ACETYLNEURAMINIC ACID; MOLECULAR MIMICRY; DERIVATIVES; OLIGOSACCHARIDES; CYTIDINE; ANALOGS;

D O I：

10.1039/b819155g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modular replacement approach to the synthesis of sulfonucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection.

引用

页码：27 / 29

页数：3

共 24 条

[21] Vinyl sulfones [J].