Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors

被引：5
作者：
Wong, Jessica H. [1 ]
Sahni, Urvashi [1 ]
Li, Yanhong [1 ]
Chen, Xi [1 ]
Gervay-Hague, Jacquelyn [1 ]
机构：
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 01期
关键词：
N-ACETYLNEURAMINIC ACID; MOLECULAR MIMICRY; DERIVATIVES; OLIGOSACCHARIDES; CYTIDINE; ANALOGS;
D O I：
10.1039/b819155g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modular replacement approach to the synthesis of sulfonucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection.
引用
收藏
页码：27 / 29
页数：3
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