Apoptosis induction in nonirradiated human HL-60 and murine NSO/2 tumor cells by photoproducts of indole-3-acetic acid and riboflavin

被引：23
作者：
Edwards, AM
Barredo, F
Silva, E
De Ioannes, AE
Becker, MI
机构：
[1] Pontificia Univ Catolica Chile, Fac Quim 536, Dept Quim Fis, Santiago 22, Chile
[2] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Santiago, Chile
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1999年 / 70卷 / 04期
关键词：
D O I：
10.1111/j.1751-1097.1999.tb08264.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of the photoproducts of indole-3-acetic acid sensitized by riboflavin on nonirradiated human HL-60 and murine NSO/2 tumor cells was studied. Severe damage with a dose-response effect was observed on both cell types. The effect was greater than that previously described for the tryptophan riboflavin photoproducts. Electron microscopy studies and flow cytometry analysis of DNA fragmentation allowed us to conclude that the photoproducts studied in this work induce cell death by an apoptotic mechanism.
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页码：645 / 649
页数：5
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