Comparison of the long-term mortality in Hodgkin's disease patients with that of the general population

被引:7
作者
Provencio, M
García-López, FJ
Bonilla, F
España, P
机构
[1] Hosp Univ Clin Puerta de Hierro, Serv Oncol, Dept Oncol, Madrid 28035, Spain
[2] Hosp Univ Clin Puerta de Hierro, Clin Epidemiol Unit, Madrid 28035, Spain
关键词
Hodgkin's disease; longitudinal study; mortality; survival analysis;
D O I
10.1023/A:1008306702211
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Although Hodgkin's disease can be treated successfully, its long-term survival rate has yet to be definitely established. We compared the long-term mortality rate of patients diagnosed as having Hodgkin's disease with that of the general population. Patients and methods: We studied a retrospective cohort of 477 patients who received pathology-confirmed diagnoses of Hodgkin's disease between 1967 and 1993 and were treated with combined chemotherapy or radiotherapy with follow-up from the day of diagnosis. Standardised mortality ratios were computed with reference rates taken from the Spanish population. Results: The follow-up was complete for 427 (89.5%) of the patients. The median follow-up time was 8 years, 133 patients (28%) died and the median survival time was 21 years. The overall survival rates were 80% at 5 years, 70% at 10 years, and 64% at 15 years after diagnosis. The standardised mortality ratios were 10.8 (95% confidence interval: 9.0-12.8, P < 0.0001) overall, 5.5 in patients in favourable stages (IA, IIA), and 15.2 in those with unfavourable stages (IB, IIB, III, IV). There was a decreasing trend in mortality by calendar period (standardised mortality ratios for 1967-1975, 1976-1974 and 1985-1993: 16.8, 10.3 and 5.1, respectively). Higher mortality was observed in all periods of follow-up after diagnosis, even after 20 years. Conclusions: Despite the improvements in treatment, mortality in Hodgkin's disease remains higher than in the general population in all disease stages, even 20 years after diagnosis.
引用
收藏
页码:1199 / 1205
页数:7
相关论文
共 43 条
  • [31] Lindsey J.K., 1995, MODELLING FREQUENCY
  • [32] REPORT OF A COMMITTEE CONVENED TO DISCUSS THE EVALUATION AND STAGING OF PATIENTS WITH HODGKINS-DISEASE - COTSWOLDS MEETING
    LISTER, TA
    CROWTHER, D
    SUTCLIFFE, SB
    GLATSTEIN, E
    CANELLOS, GP
    YOUNG, RC
    ROSENBERG, SA
    COLTMAN, CA
    TUBIANA, M
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (11) : 1630 - 1636
  • [33] LOHRI A, 1991, BLOOD, V77, P2292
  • [34] LUKES RJ, 1966, CANCER RES, V26, P1063
  • [35] Mauch P M, 1995, Cancer J Sci Am, V1, P33
  • [36] CONTROVERSIES IN THE MANAGEMENT OF EARLY-STAGE HODGKINS-DISEASE
    MAUCH, PM
    [J]. BLOOD, 1994, 83 (02) : 318 - 329
  • [37] Parmar M.K. B., 1995, SURVIVAL ANAL PRACTI
  • [38] THE EVOLUTION AND SUMMARY RESULTS OF THE STANFORD RANDOMIZED CLINICAL-TRIALS OF THE MANAGEMENT OF HODGKINS-DISEASE - 1962-1984
    ROSENBERG, SA
    KAPLAN, HS
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1985, 11 (01): : 5 - 22
  • [39] Rothman K., 1982, EPIDEMIOLOGIC ANAL P
  • [40] HODGKINS-DISEASE - IS THERE A PRICE FOR SUCCESSFUL TREATMENT - A 25-YEAR EXPERIENCE
    RUBIN, P
    ZAGARS, G
    CHUANG, C
    THOMAS, EM
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1986, 12 (02): : 153 - 166