Selective Targeting Capability Acquired with a Protein Corona Adsorbed on the Surface of 1,2-Dioleoyl-3-trimethylammonium Propane/DNA Nanoparticles

被引：155

作者：

Caracciolo, Giulio ^{[1
]}

Cardarelli, Francesco ^{[2
]}

Pozzi, Daniela ^{[1
]}

Salomone, Fabrizio ^{[2
,3
,4
]}

Maccari, Giuseppe ^{[2
]}

Bardi, Giuseppe ^{[2
]}

Capriotti, Anna Laura ^{[5
]}

Cavaliere, Chiara ^{[5
]}

Papi, Massimiliano ^{[6
]}

Lagana, Aldo ^{[5
]}

机构：

[1] Univ Roma La Sapienza, Dept Mol Med, I-00161 Rome, Italy

[2] Ist Italiano Tecnol, Ctr Nanotechnol Innovat NEST, I-56127 Pisa, Italy

[3] Scuola Normale Super Pisa, NEST, I-56127 Pisa, Italy

[4] CNR, Ist Nanosci, I-56127 Pisa, Italy

[5] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[6] Catholic Univ Sch Med, Ist Fis, I-00168 Rome, Italy

来源：

ACS APPLIED MATERIALS & INTERFACES | 2013年 / 5卷 / 24期

关键词：

targeting drug delivery; nanoparticle; protein corona; cationic lipids; MOLECULAR INTERACTION DATABASE; ACCELERATED BLOOD CLEARANCE; TRANSFECTION EFFICIENCY; MEDIATED TRANSPORT; CHO-CELLS; MACROPINOCYTOSIS; EXPRESSION; INJECTION; DELIVERY; TUMORS;

D O I：

10.1021/am404171h

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A possible turning point in drug delivery has been recently reached: the protein shell, which covers nanocarriers in vivo, can be used for targeting. Here, we show that nanoparticles can acquire a selective targeting capability with a protein corona adsorbed on the surface. We demonstrate that lipid particles made of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and DNA, upon interaction with human plasma components, spontaneously become coated with vitronectin that promotes efficient uptake in cancer cells expressing high levels of the vitronectin alpha(v)beta(3) integrin receptor.

引用

页码：13171 / 13179

页数：9

共 9 条

[1] The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes
Andang Miatmoko
Febe Harum Asmoro
Andre Alwi Azhari
Noorma Rosita
Chin-Shiu Huang
Scientific Reports, 13
[2] The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes
Miatmoko, Andang
Asmoro, Febe Harum
Azhari, Andre Alwi
Rosita, Noorma
Huang, Chin-Shiu
SCIENTIFIC REPORTS, 2023, 13 (01)
[3] Extraction and quantification of the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane from human plasma
Koeber, Robert
Pappas, Apostolos
Michaelis, Uwe
Schulze, Brita
ANALYTICAL BIOCHEMISTRY, 2007, 363 (01) : 157 - 159
[4] Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
Li, Yue
Bhindi, Ravinay
Deng, Zhou J.
Morton, Stephen W.
Hammond, Paula T.
Khachigian, Levon M.
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 168 (04) : 3659 - 3664
[5] Role of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) in β-lactoglobulin aggregation
Ma, Baoliang
Wang, Xiaofei
Liu, Yujie
Li, Zhihong
Zhang, Fan
CHEMISTRY AND PHYSICS OF LIPIDS, 2018, 210 : 76 - 81
[6] Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β[N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome Retention Mediates Stronger Th1 Responses
Henriksen-Lacey, Malou
Christensen, Dennis
Bramwell, Vincent W.
Lindenstrom, Thomas
Agger, Else Marie
Andersen, Peter
Perrie, Yvonne
MOLECULAR PHARMACEUTICS, 2011, 8 (01) : 153 - 161
[7] 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)-formulated, immune-stimulatory vascular endothelial growth factor a small interfering RNA (siRNA) increases antitumoral efficacy in murine orthotopic hepatocellular
Kornek, Miroslaw
Lukacs-Kornek, Veronika
Limmer, Andreas
Raskopf, Esther
Becker, Ursula
Kloeckner, Maren
Sauerbruch, Tilman
Schmitz, Volker
MOLECULAR MEDICINE, 2008, 14 (7-8) : 365 - 373
[8] 1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis
Miroslaw Kornek
Veronika Lukacs-Kornek
Andreas Limmer
Esther Raskopf
Ursula Becker
Maren Klöckner
Tilman Sauerbruch
Volker Schmitz
Molecular Medicine, 2008, 14 : 365 - 373
[9] TARGETING GLUCOSYLCERAMIDE SYNTHASE INDUCTION OF CELL SURFACE GLOBOTRIAOSYLCERAMIDE (GB3) CO-EXPRESSED WITH MULTIDRUG RESISTANCE 1 (MDR1) PROTEIN AS NEW TREATMENT APPROACH IN ACQUIRED CISPLATIN-RESISTANCE OF MALIGNANT PLEURAL MESOTHELIOMA AND NON-SMALL CELL LUNG CANCERCISPLATIN-RESISTANCE IN A MALIGNANT MESOTHELIOMA CELL LINE
Motlagh, Parviz Behnam
Tyler, Andreas
Johansson, Anders
Karlsson, Terese
Brannstrom, Thomas
Grankvist, Kjell
JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S1062 - S1062

← 1 →