Selective Targeting Capability Acquired with a Protein Corona Adsorbed on the Surface of 1,2-Dioleoyl-3-trimethylammonium Propane/DNA Nanoparticles

被引：155

作者：

Caracciolo, Giulio ^{[1
]}

Cardarelli, Francesco ^{[2
]}

Pozzi, Daniela ^{[1
]}

Salomone, Fabrizio ^{[2
,3
,4
]}

Maccari, Giuseppe ^{[2
]}

Bardi, Giuseppe ^{[2
]}

Capriotti, Anna Laura ^{[5
]}

Cavaliere, Chiara ^{[5
]}

Papi, Massimiliano ^{[6
]}

Lagana, Aldo ^{[5
]}

机构：

[1] Univ Roma La Sapienza, Dept Mol Med, I-00161 Rome, Italy

[2] Ist Italiano Tecnol, Ctr Nanotechnol Innovat NEST, I-56127 Pisa, Italy

[3] Scuola Normale Super Pisa, NEST, I-56127 Pisa, Italy

[4] CNR, Ist Nanosci, I-56127 Pisa, Italy

[5] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[6] Catholic Univ Sch Med, Ist Fis, I-00168 Rome, Italy

来源：

ACS APPLIED MATERIALS & INTERFACES | 2013年 / 5卷 / 24期

关键词：

targeting drug delivery; nanoparticle; protein corona; cationic lipids; MOLECULAR INTERACTION DATABASE; ACCELERATED BLOOD CLEARANCE; TRANSFECTION EFFICIENCY; MEDIATED TRANSPORT; CHO-CELLS; MACROPINOCYTOSIS; EXPRESSION; INJECTION; DELIVERY; TUMORS;

D O I：

10.1021/am404171h

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A possible turning point in drug delivery has been recently reached: the protein shell, which covers nanocarriers in vivo, can be used for targeting. Here, we show that nanoparticles can acquire a selective targeting capability with a protein corona adsorbed on the surface. We demonstrate that lipid particles made of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and DNA, upon interaction with human plasma components, spontaneously become coated with vitronectin that promotes efficient uptake in cancer cells expressing high levels of the vitronectin alpha(v)beta(3) integrin receptor.

引用

页码：13171 / 13179

页数：9