Patterns of gene expression characterize T1 and T3 clear cell renal cell carcinoma subtypes

被引：5

作者：

Borys, Agnieszka M. ^{[1
]}

Seweryn, Michel ^{[1
]}

Golabek, Tomasz ^{[2
]}

Belch, Lukasz ^{[2
]}

Klimkowska, Agnieszka ^{[3
]}

Toton-zuranskal, Justyna ^{[1
]}

Machlowska, Julita ^{[1
]}

Chlosta, Piotr ^{[2
]}

Okon, Krzysztof ^{[3
]}

Wolkow, Pawel P. ^{[1
]}

机构：

[1] Jagiellonian Univ, Med Fac, Ctr Med Genom OMICRON, Med Coll, Krakow, Poland

[2] Jagiellonian Univ, Med Fac, Chair & Dept Urol, Med Coll, Krakow, Poland

[3] Jagiellonian Univ, Med Fac, Chair Pathomorphol, Med Coll, Krakow, Poland

来源：

PLOS ONE | 2019年 / 14卷 / 05期

关键词：

MOUSE MODEL; PROTEIN; METASTASIS; PROGNOSIS; TARGET; TUMORS; PAX2;

D O I：

10.1371/journal.pone.0216793

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Renal carcinoma is the 20th most common cancer worldwide. Clear cell renal cell carcinoma is the most frequent type of renal cancer. Even in patients diagnosed at an early stage, characteristics of disease progression remain heterogeneous. Up-to-date molecular classifications stratify the ccRCC samples into two clusters. We analyzed gene expression in 23 T1 or T3 ccRCC samples. Unsupervised clustering divided this group into three clusters, two of them contained pure T1 or T3 samples while one contained a mixed group. We defined a group of 36 genes that discriminate the mixed cluster. This gene set could be associated with tumor classification into a higher stage and it contained significant number of genes coding for molecular transporters, channel and transmembrane proteins. External data from TCGA used to test our findings confirmed that the expression levels of those 36 genes varied significantly between T1 and T3 tumors. In conclusion, we found a clustering pattern of gene expression, informative for heterogeneity among T1 and T3 tumors of clear cell renal cell carcinoma.

引用

页数：19

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