Mucins MUC1, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma

被引：77
作者：
Pinto-de-Sousa, J
David, L
Reis, CA
Gomes, R
Silva, L
Pimenta, A
机构：
[1] Hosp Sao Joao, Serv Cirurg 4, D-4300 Essen, Germany
[2] Univ Porto, Fac Med, Oporto, Portugal
[3] Univ Porto, Inst Mol Pathol & Immunol, IPATIMUP, Oporto, Portugal
来源：
VIRCHOWS ARCHIV | 2002年 / 440卷 / 03期
关键词：
gastric carcinoma; mucins; MUC1; MUC2; MUC5AC;
D O I：
10.1007/s00428-001-0548-y
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Normal gastric mucosa expresses MUC1 and MUC5AC in foveolar epithelium and MUC6 in mucous neck cells of the body and deep glands of the antrum. Several studies have reported aberrant expression of an under-glycosylated form of MUC1, decreased expression of "gastric" mucins and aberrant expression of "non-gastric" mucins in gastric carcinoma. In this study, we analysed the expression profile of mucins MUC1, MUC2, MUC5AC and MUC6 in 94 gastric carcinomas using immunohistochemistry. Our results showed that: (1) mucin expression is associated with tumour type (MUC5AC with diffuse and infiltrative carcinomas and MUC2 with mucinous carcinomas) but not with the clinico-biological behaviour of the tumours; and (2) mucin expression is associated with tumour location (MUC5AC with antrum carcinomas and MUC2 with cardia carcinomas), indirectly reflecting differences in tumour differentiation according to tumour location.
引用
收藏
页码：304 / 310
页数：7
相关论文
共 52 条
[11]   NEW ELEMENTS FOR AN UPDATED CLASSIFICATION OF THE CARCINOMAS OF THE STOMACH [J].
CARNEIRO, F ;
SEIXAS, M ;
SOBRINHOSIMOES, M .
PATHOLOGY RESEARCH AND PRACTICE, 1995, 191 (06) :571-584
[12]   DIFFERENTIAL APOMUCIN EXPRESSION IN NORMAL AND NEOPLASTIC HUMAN GASTROINTESTINAL TISSUES [J].
CARRATO, C ;
BALAGUE, C ;
DEBOLOS, C ;
GONZALEZ, E ;
GAMBUS, G ;
PLANAS, J ;
PERINI, JM ;
ANDREU, D ;
REAL, FX .
GASTROENTEROLOGY, 1994, 107 (01) :160-172
[13]   MUC6 APOMUCIN SHOWS A DISTINCT NORMAL TISSUE DISTRIBUTION THAT CORRELATES WITH LEWIS ANTIGEN EXPRESSION IN THE HUMAN STOMACH [J].
DEBOLOS, C ;
GARRIDO, M ;
REAL, FX .
GASTROENTEROLOGY, 1995, 109 (03) :723-734
[14]  
DESOUSA JP, 2001, DIGEST SURG, V18, P102
[15]   MONOCLONAL-ANTIBODIES REACTING WITH THE MUC2 MUCIN CORE PROTEIN [J].
DEVINE, PL ;
MCGUCKIN, MA ;
BIRRELL, GW ;
WHITEHEAD, RH ;
SACHDEV, GP ;
SHIELD, P ;
WARD, BG .
BRITISH JOURNAL OF CANCER, 1993, 67 (06) :1182-1188
[16]   DEGENERATE 87-BASE-PAIR TANDEM REPEATS CREATE HYDROPHILIC HYDROPHOBIC ALTERNATING DOMAINS IN HUMAN MUCIN PEPTIDES MAPPED TO 11P15 [J].
DUFOSSE, J ;
PORCHET, N ;
AUDIE, JP ;
DUPERAT, VG ;
LAINE, A ;
VANSEUNINGEN, I ;
MARRAKCHI, S ;
DEGAND, P ;
AUBERT, JP .
BIOCHEMICAL JOURNAL, 1993, 293 :329-337
[17]   CHARACTERIZATION OF THE HUMAN MUCIN GENE MUC5AC - A CONSENSUS CYSTEINE-RICH DOMAIN FOR 11P15 MUCIN GENES [J].
DUPERAT, VG ;
AUDIE, JP ;
DEBAILLEUL, V ;
LAINE, A ;
BUISINE, MP ;
GALIEGUEZOUITINA, S ;
PIGNY, P ;
DEGAND, P ;
AUBERT, JP ;
PORCHET, N .
BIOCHEMICAL JOURNAL, 1995, 305 :211-219
[18]   CHARACTERIZATION OF 4 MAIN CELL-TYPES IN GASTRIC-CANCER - FOVEOLAR, MUCOPEPTIC, INTESTINAL COLUMNAR AND GOBLET CELLS - AN HISTOPATHOLOGIC, HISTOCHEMICAL AND ULTRASTRUCTURAL-STUDY OF EARLY AND ADVANCED TUMORS [J].
FIOCCA, R ;
VILLANI, L ;
TENTI, P ;
SOLCIA, E ;
CORNAGGIA, M ;
FRIGERIO, B ;
CAPELLA, C .
PATHOLOGY RESEARCH AND PRACTICE, 1987, 182 (03) :308-325
[19]  
GAMBUS G, 1993, GASTROENTEROLOGY, V104, P93
[20]  
GENDLER SJ, 1990, J BIOL CHEM, V265, P15286
123456