BCL2-like 11 intron 2 deletion polymorphism is not associated with non-small cell lung cancer risk and prognosis

被引:9
作者
Cho, Eun Na [1 ]
Kim, Eun Young [1 ]
Jung, Ji Ye [1 ]
Kim, Arum [1 ]
Oh, In Jae [2 ]
Kim, Young Chul [2 ]
Chang, Yoon Soo [1 ]
机构
[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[2] Chonnam Natl Univ, Hwasun Hosp, Gwangju, South Korea
关键词
bcl-2-like; 11; BIM intron 2 deletion polymorphism; Non-small cell lung cancer; Risk factors; Prognosis;
D O I
10.1016/j.lungcan.2015.07.017
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: BCL2-Like 11(BIM), which encodes a BH3-only protein, is a major pro-apoptotic molecule that facilitates cell death. We hypothesized that a BIM intron 2 deletion polymorphism increases lung cancer risk and predicts poor prognosis in non-small lung cancer (NSCLC) patients. Materials and methods: We prospectively recruited 450 lung cancer patients and 1:1 age, sex, and smoking status matched control subjects from February 2013 to April 2014 among patients treated at Severance, Gangnam Severance, and Chonnam Hwasoon Hospital. The presence of a 2903-bp genomic DNA deletion polymorphism of intron 2 of BIM was analyzed by PCR and validated by sequencing. Odds ratios were calculated by chi-square tests and survival analysis with Kaplan-Meier estimation. Results and conclusion: Sixty-nine out of 450 (153%) lung cancer patients carried the BIM deletion polymorphism, while 66 out of 450 (14.7%) control subjects carried the BIM deletion polymorphism, with an odds ratio of for lung cancer of 1.054 (9% CI; 0.731-1.519). We categorized 406 NSCLC patients according to the presence of the polymorphism and found that there were no statistically significant differences in age, sex, histologic type, or stage between subjects with and without the deletion polymorphism. The BIM deletion polymorphism did not influence overall survival (OS) or progression free survival (PFS) in our sample (OS; 37.6 vs 34.4 months (P=0.759), PFS; 49.6 vs 26.0 months (P=0.434)). These findings indicate that the BIM deletion polymorphism is common in Korean NSCLC patients but does not significantly affect the intrinsic biologic function of BH3-only protein. Furthermore, the BIM deletion polymorphism did not predict clinical outcomes in patients with NSCLC. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:106 / 110
页数:5
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