I have tried to offer a historical account of a success story, as I saw it develop from the early times when it interested only a few aficionados to the present times when it has pervaded most of cell biochemistry and physiology. It is of course the story of calcium signaling. It became my topic of work when I was a young postdoctoral fellow at The Johns Hopkins University. I entered it through a side door, that of mitochondria, which had been my area of work during my earlier days in Italy. The 1960s and 1970s were glorious times for mitochondrial calcium signaling, but the golden period was not going to last. As I have discussed below, mitochondrial calcium gradually lost appeal, entering a long period of oblivion. Its fading happened as the general area of calcium signaling was instead experiencing a phase of explosive growth, with landmark discoveries at the molecular and cellular levels. These discoveries established that calcium signaling was one of the most important areas of cell biology. However, mitochondria as calcium partners were not dead; they were only dormant. In the 1990s, they were rescued from their state of neglect to the central position of the regulation of cellular calcium signaling, which they had once rightly occupied. Meanwhile, it had also become clear that calcium is an ambivalent messenger. Hardly anything important occurs in cells without the participation of the calcium message, but calcium must be controlled with absolute precision. This is an imperative necessity, which becomes unfortunately impaired in a number of disease conditions that transform calcium into a messenger of death.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Baughman, Joshua M.
Perocchi, Fabiana
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Perocchi, Fabiana
Girgis, Hany S.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Girgis, Hany S.
Plovanich, Molly
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Plovanich, Molly
Belcher-Timme, Casey A.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Belcher-Timme, Casey A.
Sancak, Yasemin
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Sancak, Yasemin
Bao, X. Robert
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Bao, X. Robert
Strittmatter, Laura
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Strittmatter, Laura
Goldberger, Olga
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Goldberger, Olga
Bogorad, Roman L.
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MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Bogorad, Roman L.
Koteliansky, Victor
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Alnylam Pharmaceut Inc, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Koteliansky, Victor
Mootha, Vamsi K.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Baughman, Joshua M.
Perocchi, Fabiana
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Perocchi, Fabiana
Girgis, Hany S.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Girgis, Hany S.
Plovanich, Molly
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Plovanich, Molly
Belcher-Timme, Casey A.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Belcher-Timme, Casey A.
Sancak, Yasemin
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Sancak, Yasemin
Bao, X. Robert
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Bao, X. Robert
Strittmatter, Laura
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Strittmatter, Laura
Goldberger, Olga
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Goldberger, Olga
Bogorad, Roman L.
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机构:
MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Bogorad, Roman L.
Koteliansky, Victor
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Alnylam Pharmaceut Inc, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Koteliansky, Victor
Mootha, Vamsi K.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Boston, MA 02114 USA
Broad Inst, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02114 USA