Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

被引：68

作者：

Lim, Jing Quan ^{[1
,2
,3
]}

Huang, Dachuan ^{[2
,3
]}

Tang, Tiffany ^{[4
]}

Tan, Daryl ^{[5
,6
]}

Laurensia, Yurike ^{[2
]}

Peng, Rou-Ju ^{[1
]}

Wong, Esther Kam Yin ^{[2
]}

Cheah, Daryl Ming Zhe ^{[2
]}

Chia, Burton Kuan Hui ^{[2
]}

Iqbal, Jabed ^{[7
]}

Grigoropoulos, Nicholas Francis ^{[6
]}

Nairismagi, Maarja-Liisa ^{[2
]}

Ng, Cedric Chuan Young ^{[8
,9
]}

Rajasegaran, Vikneswari ^{[8
,9
]}

Hong, Huangming ^{[1
,10
]}

Kim, Seok Jin ^{[11
]}

Cho, Junhun ^{[12
]}

Tse, Eric ^{[13
]}

Mow, Benjamin ^{[14
]}

Cai, Qi-Chun ^{[15
]}

Poon, Li-Mei ^{[16
]}

Cai, Qing-qing ^{[1
]}

Tan, Jing ^{[1
,2
,8
]}

Chan, Jason Yongsheng ^{[4
]}

Lim, Johnathan Xiande ^{[7
]}

Goh, Yeow Tee ^{[6
]}

Phipps, Colin ^{[6
]}

Rotzschke, Olaf ^{[17
]}

Cheng, Chee Leong ^{[7
]}

Ha, Jeslin Chian Hung ^{[18
]}

Khoo, Lay Poh ^{[18
]}

Loh, Yvonne Su Ming ^{[5
,6
]}

Au-Yeung, Rex ^{[19
]}

Chan, Thomas Sau-Yan ^{[13
]}

Kwong, Yok-Lam ^{[13
]}

Hwang, William ^{[20
]}

Kim, Won Seog ^{[11
]}

Bei, Jin-Xin ^{[1
]}

Lin, Tongyu ^{[1
,10
]}

Ong, Choon Kiat ^{[2
,21
,22
]}

Lim, Soon Thye ^{[20
,23
]}

机构：

[1] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[2] Natl Canc Ctr Singapore, Lymphoma Genom Translat Res Lab, Cellular & Mol Res, 11 Hosp Dr, Singapore 169610, Singapore

[3] Duke NUS Med Sch, ONCO ACP, 8 Coll Rd, Singapore 169857, Singapore

[4] Natl Canc Ctr Singapore, Div Med Oncol, 11 Hosp Dr, Singapore 169610, Singapore

[5] Raffles Hosp, Raffles Canc Ctr, 585 North Bridge Rd 10-00, Singapore 188770, Singapore

[6] Singapore Gen Hosp, Dept Haematol, Outram Rd, Singapore 169608, Singapore

[7] Singapore Gen Hosp, Dept Pathol, 20 Coll Rd, Singapore 169856, Singapore

[8] Natl Canc Ctr, Lab Canc Epigenome, Div Med Sci, 11 Hosp Dr, Singapore 169610, Singapore

[9] Duke NUS Med Sch, Div Canc & Stem Cell Biol, 8 Coll Rd, Singapore 169857, Singapore

[10] Sun Yat Sen Univ, Canc Ctr, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China

[11] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Hematol Oncol, Seoul, South Korea

[12] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea

[13] Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam, Hong Kong, Peoples R China

[14] Mt Elizabeth Med Ctr, Singapore, Singapore

[15] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China

[16] Natl Univ Hlth Syst, Natl Univ Canc Inst Singapore, Dept Haematol Oncol, Singapore, Singapore

[17] ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove, Singapore 138648, Singapore

[18] Natl Canc Ctr Singapore, Div Med Oncol, Lymphoma Genom Translat Res Lab, 11 Hosp Dr, Singapore 169610, Singapore

[19] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Pokfulam, Hong Kong, Peoples R China

[20] Natl Canc Ctr Singapore, Directors Off, Singapore, Singapore

[21] Genome Inst Singapore, 60 Biopolis St Genome, Singapore 138672, Singapore

[22] Duke NUS Grad Med Sch, 8 Coll Rd, Singapore 169857, Singapore

[23] Duke NUS Med Sch, Off Educ, Singapore, Singapore

来源：

LEUKEMIA | 2020年 / 34卷 / 12期

基金：

英国医学研究理事会; 美国国家科学基金会;

关键词：

GENETIC RISK;

D O I：

10.1038/s41375-020-1000-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：3413 / 3419

页数：7

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