Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

被引：66

作者：

Lim, Jing Quan ^{[1
,2
,3
]}

Huang, Dachuan ^{[2
,3
]}

Tang, Tiffany ^{[4
]}

Tan, Daryl ^{[5
,6
]}

Laurensia, Yurike ^{[2
]}

Peng, Rou-Ju ^{[1
]}

Wong, Esther Kam Yin ^{[2
]}

Cheah, Daryl Ming Zhe ^{[2
]}

Chia, Burton Kuan Hui ^{[2
]}

Iqbal, Jabed ^{[7
]}

Grigoropoulos, Nicholas Francis ^{[6
]}

Nairismagi, Maarja-Liisa ^{[2
]}

Ng, Cedric Chuan Young ^{[8
,9
]}

Rajasegaran, Vikneswari ^{[8
,9
]}

Hong, Huangming ^{[1
,10
]}

Kim, Seok Jin ^{[11
]}

Cho, Junhun ^{[12
]}

Tse, Eric ^{[13
]}

Mow, Benjamin ^{[14
]}

Cai, Qi-Chun ^{[15
]}

Poon, Li-Mei ^{[16
]}

Cai, Qing-qing ^{[1
]}

Tan, Jing ^{[1
,2
,8
]}

Chan, Jason Yongsheng ^{[4
]}

Lim, Johnathan Xiande ^{[7
]}

Goh, Yeow Tee ^{[6
]}

Phipps, Colin ^{[6
]}

Rotzschke, Olaf ^{[17
]}

Cheng, Chee Leong ^{[7
]}

Ha, Jeslin Chian Hung ^{[18
]}

Khoo, Lay Poh ^{[18
]}

Loh, Yvonne Su Ming ^{[5
,6
]}

Au-Yeung, Rex ^{[19
]}

Chan, Thomas Sau-Yan ^{[13
]}

Kwong, Yok-Lam ^{[13
]}

Hwang, William ^{[20
]}

Kim, Won Seog ^{[11
]}

Bei, Jin-Xin ^{[1
]}

Lin, Tongyu ^{[1
,10
]}

Ong, Choon Kiat ^{[2
,21
,22
]}

Lim, Soon Thye ^{[20
,23
]}

机构：

[1] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[2] Natl Canc Ctr Singapore, Lymphoma Genom Translat Res Lab, Cellular & Mol Res, 11 Hosp Dr, Singapore 169610, Singapore

[3] Duke NUS Med Sch, ONCO ACP, 8 Coll Rd, Singapore 169857, Singapore

[4] Natl Canc Ctr Singapore, Div Med Oncol, 11 Hosp Dr, Singapore 169610, Singapore

[5] Raffles Hosp, Raffles Canc Ctr, 585 North Bridge Rd 10-00, Singapore 188770, Singapore

[6] Singapore Gen Hosp, Dept Haematol, Outram Rd, Singapore 169608, Singapore

[7] Singapore Gen Hosp, Dept Pathol, 20 Coll Rd, Singapore 169856, Singapore

[8] Natl Canc Ctr, Lab Canc Epigenome, Div Med Sci, 11 Hosp Dr, Singapore 169610, Singapore

[9] Duke NUS Med Sch, Div Canc & Stem Cell Biol, 8 Coll Rd, Singapore 169857, Singapore

[10] Sun Yat Sen Univ, Canc Ctr, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China

[11] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Hematol Oncol, Seoul, South Korea

[12] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea

[13] Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam, Hong Kong, Peoples R China

[14] Mt Elizabeth Med Ctr, Singapore, Singapore

[15] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China

[16] Natl Univ Hlth Syst, Natl Univ Canc Inst Singapore, Dept Haematol Oncol, Singapore, Singapore

[17] ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove, Singapore 138648, Singapore

[18] Natl Canc Ctr Singapore, Div Med Oncol, Lymphoma Genom Translat Res Lab, 11 Hosp Dr, Singapore 169610, Singapore

[19] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Pokfulam, Hong Kong, Peoples R China

[20] Natl Canc Ctr Singapore, Directors Off, Singapore, Singapore

[21] Genome Inst Singapore, 60 Biopolis St Genome, Singapore 138672, Singapore

[22] Duke NUS Grad Med Sch, 8 Coll Rd, Singapore 169857, Singapore

[23] Duke NUS Med Sch, Off Educ, Singapore, Singapore

来源：

LEUKEMIA | 2020年 / 34卷 / 12期

基金：

美国国家科学基金会; 英国医学研究理事会;

关键词：

GENETIC RISK;

D O I：

10.1038/s41375-020-1000-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：3413 / 3419

页数：7

共 15 条

[1] PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma
Bi, Xi-wen
Wang, Hua
Zhang, Wen-wen
Wang, Jing-hua
Liu, Wen-jian
Xia, Zhong-jun
Huang, Hui-qiang
Jiang, Wen-qi
Zhang, Yu-jing
Wang, Liang
[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2016, 9
[2] Chan JKC., 2008, World health organization classification of tumors: pathology and genetics of tumors of haematopoietic and lymphoid tissues, P285
[3] Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification
Cheson, Bruce D.
Fisher, Richard I.
Barrington, Sally F.
Cavalli, Franco
Schwartz, Lawrence H.
Zucca, Emanuele
Lister, T. Andrew
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) : 3059 - +
[4] Immune checkpoint inhibitors: recent progress and potential biomarkers
Darvin, Pramod
Toor, Salman M.
Nair, Varun Sasidharan
Elkord, Eyad
[J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, 50 : 1 - 11
[5] The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Havel, Jonathan J.
Chowell, Diego
Chan, Timothy A.
[J]. NATURE REVIEWS CANCER, 2019, 19 (03) : 133 - 150
[6] Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
Kataoka, Keisuke
Shiraishi, Yuichi
Takeda, Yohei
Sakata, Seiji
Matsumoto, Misako
Nagano, Seiji
Maeda, Takuya
Nagata, Yasunobu
Kitanaka, Akira
Mizuno, Seiya
Tanaka, Hiroko
Chiba, Kenichi
Ito, Satoshi
Watatani, Yosaku
Kakiuchi, Nobuyuki
Suzuki, Hiromichi
Yoshizato, Tetsuichi
Yoshida, Kenichi
Sanada, Masashi
Itonaga, Hidehiro
Imaizumi, Yoshitaka
Totoki, Yasushi
Munakata, Wataru
Nakamura, Hiromi
Hama, Natsuko
Shide, Kotaro
Kubuki, Yoko
Hidaka, Tomonori
Kameda, Takuro
Masuda, Kyoko
Minato, Nagahiro
Kashiwase, Koichi
Izutsu, Koji
Takaori-Kondo, Akifumi
Miyazaki, Yasushi
Takahashi, Satoru
Shibata, Tatsuhiro
Kawamoto, Hiroshi
Akatsuka, Yoshiki
Shimoda, Kazuya
Takeuchi, Kengo
Seya, Tsukasa
Miyano, Satoru
Ogawa, Seishi
[J]. NATURE, 2016, 534 (7607) : 402 - +
[7] PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing L-asparaginase
Kwong, Yok-Lam
Chan, Thomas S. Y.
Tan, Daryl
Kim, Seok Jin
Poon, Li-Mei
Mow, Benjamin
Khong, Pek-Lan
Loong, Florence
Au-Yeung, Rex
Iqbal, Jabed
Phipps, Colin
Tse, Eric
[J]. BLOOD, 2017, 129 (17) : 2437 - 2442
[8] Activity of pembrolizumab in relapsed/refractory NK/T-cell lymphoma
Li, Xin
Cheng, Yasong
Zhang, Mingzhi
Yan, Jiaqin
Li, Ling
Fu, Xiaorui
Zhang, Xudong
Chang, Yu
Sun, Zhenchang
Yu, Hui
Zhang, Lei
Wang, Xinhua
Wu, Jingjing
Li, Zhaoming
Nan, Feifei
Tian, Li
Li, Wencai
Young, Ken H.
[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11
[9] Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study
Li, Zheng
Xia, Yi
Feng, Li-Na
Chen, Jie-Rong
Li, Hong-Min
Cui, Jing
Cai, Qing-Qing
Sim, Kar Seng
Nairismagi, Maarja-Liisa
Laurensia, Yurike
Meah, Wee Yang
Liu, Wen-Sheng
Guo, Yun-Miao
Chen, Li-Zhen
Feng, Qi-Sheng
Pang, Chi Pui
Chen, Li Jia
Chew, Soo Hong
Ebstein, Richard P.
Foo, Jia Nee
Liu, Jianjun
Ha, Jeslin
Khoo, Lay Poh
Chin, Suk Teng
Zeng, Yi-Xin
Aung, Tin
Chowbay, Balram
Diong, Colin Phipps
Zhang, Fen
Liu, Yan-Hui
Tang, Tiffany
Tao, Miriam
Quek, Richard
Mohamad, Farid
Tan, Soo Yong
Teh, Bin Tean
Ng, Siok Bian
Chng, Wee Joo
Ong, Choon Kiat
Okada, Yukinori
Raychaudhuri, Soumya
Lim, Soon Thye
Tan, Wen
Peng, Rou-Jun
Khor, Chiea Chuen
Bei, Jin-Xin
[J]. LANCET ONCOLOGY, 2016, 17 (09) : 1240 - 1247
[10] Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations
Lin, Guo-Wang
Xu, Caigang
Chen, Kexin
Huang, Hui-Qiang
Chen, Jieping
Song, Bao
Chan, John K. C.
Li, Wenyu
Liu, Weiping
Shih, Lee-Yung
Chuang, Wen-Yu
Kim, Won Seog
Tan, Wen
Peng, Rou-Jun
Laurensia, Yurike
Cheah, Daryl Ming Zhe
Huang, DaChuan
Cheng, Chee Leong
Su, Yi-Jiun
Tan, Soo-Yong
Ng, Siok-Bian
Tang, Tiffany Pooi Ling
Han, Kyudong
Wang, Vivien Ya-Fan
Jia, Wei-Hua
Pei, Zhong
Li, Ya-Jun
Gao, Song
Shi, Yongyong
Hu, Zhibin
Zhang, Furen
Zhang, Ben
Zeng, Yi-Xin
Shen, Hongbing
He, Lin
Ong, Choon Kiat
Lim, Soon Thye
Chanock, Stephen
Kwong, Yok-Lam
Lin, Dongxin
Rothman, Nathaniel
Khor, Chiea Chuen
Lan, Qing
Bei, Jin-Xin
[J]. LANCET ONCOLOGY, 2020, 21 (02) : 306 - 316

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