Efficient synthesis of β2-amino acid by homologation of α-amino acids involving the Reformatsky reaction and Mannich-type imminium electrophile

被引：77

作者：

Moumne, R

Lavielle, S

Karoyan, P

机构：

[1] Univ Paris 06, CNRS, UMR 7613, F-75252 Paris 05, France

[2] Senn Chem AG, CH-8157 Dielsdorf, Switzerland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 08期

关键词：

D O I：

10.1021/jo060316a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Development of new methods for the synthesis of P-amino acids is important as polymers of these compounds are promising peptidomimetic candidates in medicinal chemistry. We report here our findings on a new and highly efficient general strategy for the synthesis of beta(2)-amino acids by homologation of a.-amino acids, involving the Reformatsky reaction and Mannich-type imminium electrophile.

引用

页码：3332 / 3334

页数：3

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