Efficient synthesis of β2-amino acid by homologation of α-amino acids involving the Reformatsky reaction and Mannich-type imminium electrophile

Development of new methods for the synthesis of P-amino acids is important as polymers of these compounds are promising peptidomimetic candidates in medicinal chemistry. We report here our findings on a new and highly efficient general strategy for the synthesis of beta(2)-amino acids by homologation of a.-amino acids, involving the Reformatsky reaction and Mannich-type imminium electrophile.