Antigen Presentation to B Cells

被引：118

作者：

Heesters, Balthasar A. ^{[1
,2
,3
]}

van der Poel, Cees E. ^{[1
,2
]}

Das, Abhishek ^{[1
,2
]}

Carroll, Michael C. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Program Cellular & Mol Med, Boston Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[3] Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2016年 / 37卷 / 12期

基金：

美国国家卫生研究院;

关键词：

FOLLICULAR DENDRITIC CELLS; SUBCAPSULAR SINUS MACROPHAGES; GERMINAL-CENTERS; LYMPH-NODE; AFFINITY MATURATION; IMMUNE-COMPLEXES; IN-VIVO; RHEUMATOID-ARTHRITIS; ANTIBODY-PRODUCTION; CLONAL SELECTION;

D O I：

10.1016/j.it.2016.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. In this review we discuss how native antigen is presented to B cells and its impact at several stages of B cell responses.

引用

页码：844 / 854

页数：11

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