Antigen Presentation to B Cells

被引：114
|
作者：
Heesters, Balthasar A. [1 ,2 ,3 ]
van der Poel, Cees E. [1 ,2 ]
Das, Abhishek [1 ,2 ]
Carroll, Michael C. [1 ,2 ]
机构：
[1] Harvard Med Sch, Program Cellular & Mol Med, Boston Childrens Hosp, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA
[3] Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands
来源：
TRENDS IN IMMUNOLOGY | 2016年 / 37卷 / 12期
基金：
美国国家卫生研究院;
关键词：
FOLLICULAR DENDRITIC CELLS; SUBCAPSULAR SINUS MACROPHAGES; GERMINAL-CENTERS; LYMPH-NODE; AFFINITY MATURATION; IMMUNE-COMPLEXES; IN-VIVO; RHEUMATOID-ARTHRITIS; ANTIBODY-PRODUCTION; CLONAL SELECTION;
D O I：
10.1016/j.it.2016.10.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. In this review we discuss how native antigen is presented to B cells and its impact at several stages of B cell responses.
引用
收藏
页码：844 / 854
页数：11
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