Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

被引：233

作者：

Pitkaenen, Asla ^{[1
,2
]}

Lukasiuk, Katarzyna ^{[3
]}

机构：

[1] Univ Kuopio, Dept Neurobiol, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland

[3] Polish Acad Sci, M Nencki Inst Expt Biol, Warsaw, Poland

来源：

EPILEPSY & BEHAVIOR | 2009年 / 14卷

基金：

芬兰科学院;

关键词：

Brain; Epilepsy; Gene expression; Epileptogenesis; Microarrays; Posttraumatic epilepsy; Status epilepticus; TEMPORAL-LOBE EPILEPSY; DENTATE GRANULE CELLS; SEIZURES INDUCE PROLIFERATION; ASPARTATE RECEPTOR BLOCKADE; NG2-EXPRESSING GLIAL-CELLS; INDUCED STATUS EPILEPTICUS; FLUID PERCUSSION INJURY; RAT MODEL; ELECTROCONVULSIVE SEIZURES; MOOD STABILIZER;

D O I：

10.1016/j.yebeh.2008.09.023

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a cascade of molecular and cellular changes that eventually lead to the occurrence of spontaneous seizures. Cellular alterations include neurodegeneration, neurogenesis, axonal sprouting, axonal injury, dendritic remodeling, gliosis, invasion of inflammatory cells, angiogenesis. alterations in extracellular matrix, and acquired channelopathies. Large-scale molecular profiling of epileptogenic tissue has provided information about the molecular pathways that can initiate and maintain cellular alterations. Currently we are learning how these pathways Contribute to postinjury epileptogenesis and recovery process and whether they could be used as treatment targets. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：16 / 25

页数：10

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