Facile one-pot synthesis of L-proline-stabilized fluorescent gold nanoclusters and its application as sensing probes for serum iron

被引：123

作者：

Mu, Xiaoyu ^{[1
,2
]}

Qi, Li ^{[1
]}

Dong, Ping ^{[3
,4
]}

Qiao, Juan ^{[1
]}

Hou, Jian ^{[1
,2
]}

Nie, Zongxiu ^{[1
]}

Ma, Huimin ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Med Sci, Plast Surg Hosp, Res Ctr, Beijing 100144, Peoples R China

[4] Peking Union Med Coll, Beijing 100144, Peoples R China

来源：

BIOSENSORS & BIOELECTRONICS | 2013年 / 49卷

关键词：

L-proline; Gold nanocluster; Fluorescence; Ferric ion; Serum iron; ATOMIC ABSORPTION SPECTROPHOTOMETRY; BINDING CAPACITY; QUANTUM DOTS; INFRARED LUMINESCENCE; DIRECTED SYNTHESIS; AU NANOCLUSTERS; CLUSTERS; NANOPARTICLES; WATER; REDUCTION;

D O I：

10.1016/j.bios.2013.05.019

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Gold nanoclusters (Au NCs) possess outstanding physical and chemical attributes that make them excellent scaffolds for the construction of novel chemical and biological sensors. In this study, a simple one-pot synthesis method, employing L-proline as the stabilizer, was presented for preparation of fluorescent Au NCs. This strategy allowed the generation of water-soluble Au NCs within a short time of 15 min. The as-prepared Au NCs exhibited a bluish fluorescence emission at 440 nm and a quantum yield of 2.94%. Based on the aggregation-induced fluorescence quenching mechanism, the Au NCs provided favorable biocompatibility, high sensitivity and good selectivity for the measurement of ferric ion (Fe3+). Furthermore, serum samples were analyzed for the serum iron contents by using this proposed biocompatible fluorescent sensor, indicating the potential value of this Au NCs-based fluorescent sensor for application in biological and clinical analysis. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：249 / 255

页数：7

共 70 条

[1] Iron metabolism [J].