Phenolic compounds from the bark of Oroxylum indicum activate the Ngn2 promoter

被引：13

作者：

Fuentes, Rolly G. ^{[1
,4
]}

Arai, Midori A. ^{[1
]}

Sadhu, Samir K. ^{[2
]}

Ahmed, Firoj ^{[3
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Chiba 2608675, Japan

[2] Khulna Univ, Sch Life Sci, Pharm Discipline, Khulna 9208, Bangladesh

[3] Univ Dhaka, Dept Pharmaceut Chem, Dhaka 1000, Bangladesh

[4] Univ Philippines, Visayas Tacloban Coll, Tacloban City, Philippines

来源：

JOURNAL OF NATURAL MEDICINES | 2015年 / 69卷 / 04期

基金：

日本学术振兴会;

关键词：

bHLH; Flavonoids; Neurite; NEURAL STEM-CELLS; NEURONAL DIFFERENTIATION; PROGENITOR CELLS; NEUROGENESIS; MULTIPOTENCY; INHIBITION; CHRYSIN; GENES; ACID; FATE;

D O I：

10.1007/s11418-015-0919-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A reporter gene assay that detects neurogenin 2 (Ngn2) promoter activity was utilized to identify compounds that induce neuronal differentiation. Ngn2 is a basic helix-loop-helix transcription factor that activates transcription of pro-neural genes. Using this assay system and an activity-guided approach, seven phenolic compounds were isolated from the methanol extract of Oroxylum indicum: 1 oroxylin A, 2 chrysin, 3 hispidulin, 4 baicalein, 5 apigenin, 6 baicalin, and 7 isoverbascoside. Compounds 1 and 2 induced an estimated 2.7-fold increase in Ngn2 promoter activity, whereas 3 increased the activity by 2.5-fold. Furthermore, 1 and 2 enhanced neuronal differentiation of C17.2 cells, which are multipotent stem cells. [GRAPHICS] .

引用

页码：589 / 594

页数：6

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