Aerobic Multicomponent Tandem Synthesis of 3-Sulfenylimidazo[1,2-a] pyridines from Ketones, 2-Aminopyridines, and Disulfides

被引：104

作者：

Ge, Wenlei ^{[1
]}

Zhu, Xun ^{[1
,2
]}

Wei, Yunyang ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

[2] Yancheng Inst Ind Technol, Dept Chem Engn, Yancheng, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 27期

关键词：

Multicomponent reactions; Tandem reactions; C-H functionalization; Cerium; Sulfur; Ketones; ONE-POT SYNTHESIS; CATALYZED OXIDATIVE SYSTEM; COUPLING REACTION; C-C; EFFICIENT PROCEDURE; PALLADIUM; INDOLES; ALDEHYDES; IODINE; 3-SULFENYLATION;

D O I：

10.1002/ejoc.201300905

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An aerobic CeCl3 center dot 7H(2)O/NaI-catalyzed C-H functionalization reaction was developed for the synthesis of 3-sulfenylimidazo[1,2-alpha]pyridines from easily available ketones, 2-aminopyridines, and disulfides without DMSO or peroxide as an oxidant. This three-component tandem reaction process involves the formation of imidazo[1,2-alpha]pyridines followed by Friedel-Crafts sulfenylation in one pot under mild conditions. Both aryl and alkyl ketones afforded the desired products in good to excellent yields without the presence of other additives.

引用

页码：6015 / 6020

页数：6

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