Aerobic Multicomponent Tandem Synthesis of 3-Sulfenylimidazo[1,2-a] pyridines from Ketones, 2-Aminopyridines, and Disulfides

被引：103
|
作者：
Ge, Wenlei [1 ]
Zhu, Xun [1 ,2 ]
Wei, Yunyang [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China
[2] Yancheng Inst Ind Technol, Dept Chem Engn, Yancheng, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 27期
关键词：
Multicomponent reactions; Tandem reactions; C-H functionalization; Cerium; Sulfur; Ketones; ONE-POT SYNTHESIS; CATALYZED OXIDATIVE SYSTEM; COUPLING REACTION; C-C; EFFICIENT PROCEDURE; PALLADIUM; INDOLES; ALDEHYDES; IODINE; 3-SULFENYLATION;
D O I：
10.1002/ejoc.201300905
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An aerobic CeCl3 center dot 7H(2)O/NaI-catalyzed C-H functionalization reaction was developed for the synthesis of 3-sulfenylimidazo[1,2-alpha]pyridines from easily available ketones, 2-aminopyridines, and disulfides without DMSO or peroxide as an oxidant. This three-component tandem reaction process involves the formation of imidazo[1,2-alpha]pyridines followed by Friedel-Crafts sulfenylation in one pot under mild conditions. Both aryl and alkyl ketones afforded the desired products in good to excellent yields without the presence of other additives.
引用
收藏
页码：6015 / 6020
页数：6
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