Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium

被引：5

作者：

Martino, Alessandro ^{[1
]}

Sainz, Juan ^{[2
,3
]}

Reis, Rui Manuel ^{[4
,5
]}

Moreno, Victor ^{[6
,7
]}

Buda, Gabriele ^{[8
]}

Lesueur, Fabienne ^{[9
]}

Marques, Herlander ^{[4
]}

Garcia-Sanz, Ramon ^{[10
]}

Rios, Rafael ^{[2
,3
]}

Stein, Angelika ^{[1
]}

Dumontet, Charles ^{[11
]}

Gemignani, Federica ^{[12
]}

Rossi, Anna Maria ^{[12
]}

Landi, Stefano ^{[12
]}

Jurado, Manuel ^{[2
,3
]}

Petrini, Mario ^{[8
]}

Jamroziak, Krzysztof ^{[13
]}

Campa, Daniele ^{[1
]}

Canzian, Federico ^{[1
]}

机构：

[1] German Canc Res Ctr, Genom Epidemiol Grp, D-69120 Heidelberg, Germany

[2] Genyo Pfizer Univ Granada Andalusian Govt Ctr Gen, Genom Oncol Area, Granada, Spain

[3] Virgen de las Nieves Univ Hosp, Dept Hematol, Granada, Spain

[4] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal

[5] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil

[6] Univ Barcelona, IDIBELL, Catalan Inst Oncol, Barcelona, Spain

[7] Univ Barcelona, CIBERESP, Barcelona, Spain

[8] Pisa Univ Hosp, Sect Hematol, Dept Oncol Transplants & Adv Technol, Pisa, Italy

[9] IARC, Genet Canc Susceptibil Grp, Lyon, France

[10] Univ Salamanca, CSIC, Univ Hosp Salamanca, E-37008 Salamanca, Spain

[11] Univ Lyon 1, Fac Med Rockefeller, Lab Cytol Analyt, INSERM,UMR 1052,CNRS 5286, F-69365 Lyon, France

[12] Univ Pisa, Genet Sect, Dept Biol, Pisa, Italy

[13] Med Univ Lodz, Dept Hematol, Lodz, Poland

来源：

JOURNAL OF HUMAN GENETICS | 2013年 / 58卷 / 03期

关键词：

association studies; CAR; genetic susceptibility; multiple myeloma; PXR; UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHY; CHEMICALS; EXPOSURE;

D O I：

10.1038/jhg.2012.149

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The exposure to pesticides and toxic compounds in xenobiotic transport and metabolism genes has been shown to affect risk of developing multiple myeloma (MM). Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) could determine a difference in MM susceptibility. Ten tagging single-nucleotide polymorphisms (SNPs) for PXR and seven for the CAR genes were selected and genotyped in 627 MM cases and 883 controls collected in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium. None of the 17 SNPs investigated showed significant association with MM risk either alone or when combined in haplotypes. Significant SNP-SNP interactions were not found, neither with 58 previously genotyped polymorphisms in ABC transporters. We can therefore exclude that common genetic variants in the xenobiotic transport and metabolism regulator genes PXR and CAR affect MM risk. Journal of Human Genetics (2013) 58, 155-159; doi:10.1038/jhg.2012.149; published online 10 January 2013

引用

页码：155 / 159

页数：5

共 23 条

[1] Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium [J].

Campa, Daniele ;

Martino, Alessandro ;

Sainz, Juan ;

Buda, Gabriele ;

Jamroziak, Krzysztof ;

Weinhold, Niels ;

Vieira Reis, Rui Manuel ;

Garcia-Sanz, Ramon ;

Jurado, Manuel ;

Rios, Rafael ;

Szemraj-Rogucka, Zofia ;

Marques, Herlander ;

Lesueur, Fabienne ;

Bugert, Peter ;

Moreno, Victor ;

Szemraj, Janusz ;

Orciuolo, Enrico ;

Gemignani, Federica ;

Rossi, Anna Maria ;

Dumontet, Charles ;

Petrini, Mario ;

Goldschmidt, Hartmut ;

Landi, Stefano ;

Canzian, Federico .

BRITISH JOURNAL OF HAEMATOLOGY, 2012, 157 (03) :331-338

[2] SNP-tools: A compact tool package for analysis and conversion of genotype data for MS-Excel [J].

Chen B. ;

Wilkening S. ;

Drechsel M. ;

Hemminki K. .

BMC Research Notes, 2 (1)

[3]

Ferlay J, 2010, IARC CANCERBASE

[4] A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms [J].

Gao, Xiaoyi ;

Stamier, Joshua ;

Martin, Eden R. .

GENETIC EPIDEMIOLOGY, 2008, 32 (04) :361-369

[5]

Hernandez J. P., 2009, Current Pharmacogenomics & Personalized Medicine, V7, P81

[6] An Update of Cancer Incidence in the Agricultural Health Study [J].

Koutros, Stella ;

Alavanja, Michael C. R. ;

Lubin, Jay H. ;

Sandler, Dale P. ;

Hoppin, Jane A. ;

Lynch, Charles F. ;

Knott, Charles ;

Blair, Aaron ;

Freeman, Laura E. Beane .

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2010, 52 (11) :1098-1105

[7]

Kyle RA, 2003, BRIT J HAEMATOL, V121, P749

[8] Long-term follow-up of 241 patients with monoclonal Gammopathy of undetermined significance: The original Mayo clinic series 25 years later [J].

Kyle, RA ;

Therneau, TM ;

Rajkumar, SV ;

Larson, DR ;

Plevak, MF ;

Melton, LJ .

MAYO CLINIC PROCEEDINGS, 2004, 79 (07) :859-866

[9] Pharmacogenetics of the constitutive androstane receptor [J].

Lamba, Jatinder K. .

PHARMACOGENOMICS, 2008, 9 (01) :71-83

[10] Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis [J].

Landgren, O. ;

Weiss, B. M. .

LEUKEMIA, 2009, 23 (10) :1691-1697

← 1 2 3 →