Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study

被引：270

作者：

von Renteln, Daniel ^{[1
]}

Fuchs, Karl-Hermann ^{[4
]}

Fockens, Paul ^{[5
]}

Bauerfeind, Peter ^{[6
]}

Vassiliou, Melina C. ^{[7
]}

Werner, Yuki B. ^{[2
]}

Fried, Gerald ^{[7
]}

Breithaupt, Wolfram ^{[4
]}

Heinrich, Henriette ^{[6
]}

Bredenoord, Albert J. ^{[5
]}

Kersten, Jan F. ^{[3
]}

Verlaan, Tessa ^{[5
]}

Trevisonno, Michael ^{[7
]}

Roesch, Thomas ^{[1
]}

机构：

[1] Univ Hosp Hamburg Eppendorf, Dept Interdisciplinary Endoscopy, Hamburg, Germany

[2] Univ Hosp Hamburg Eppendorf, Dept Gastroenterol, Hamburg, Germany

[3] Univ Hosp Hamburg Eppendorf, Dept Med Biometry & Epidemiol, Hamburg, Germany

[4] Markus Krankenhaus Frankfurt, Dept Surg, Frankfurt, Germany

[5] Acad Med Ctr, Dept Gastroenterol, Amsterdam, Netherlands

[6] Univ Zurich Hosp, Dept Gastroenterol, CH-8091 Zurich, Switzerland

[7] McGill Univ, Dept Surg, Montreal, PQ H3A 2T5, Canada

来源：

GASTROENTEROLOGY | 2013年 / 145卷 / 02期

关键词：

POEM; Peroral Endoscopic Myotomy; Endoscopic Therapy; Esophageal Motility Disorder; LES; PROSPECTIVE SINGLE-CENTER; ESOPHAGEAL ACHALASIA; HELLER MYOTOMY; POEM; OUTCOMES;

D O I：

10.1053/j.gastro.2013.04.057

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months.

引用

页码：309 / +

页数：6

共 14 条

[1] Pneumatic Dilation versus Laparoscopic Heller's Myotomy for Idiopathic Achalasia [J].

Boeckxstaens, Guy E. ;

Annese, Vito ;

des Varannes, Stanislas Bruley ;

Chaussade, Stanislas ;

Costantini, Mario ;

Cuttitta, Antonello ;

Ignasi Elizalde, J. ;

Fumagalli, Uberto ;

Gaudric, Marianne ;

Rohof, Wout O. ;

Smout, Andre J. ;

Tack, Jan ;

Zwinderman, Aeilko H. ;

Zaninotto, Giovanni ;

Busch, Olivier R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (19) :1807-1816

[2] Endoscopic and Surgical Treatments for Achalasia A Systematic Review and Meta-Analysis [J].

Campos, Guilherme M. ;

Vittinghoff, Eric ;

Rabl, Charlotte ;

Takata, Mark ;

Gadenstaetter, Michael ;

Lin, Feng ;

Ciovica, Ruxandra .

ANNALS OF SURGERY, 2009, 249 (01) :45-57

[3] Peroral endoscopic myotomy (POEM) for oesophageal achalasia: Preliminary results in humans [J].

Costamagna, Guido ;

Marchese, Michele ;

Familiari, Pietro ;

Tringali, Andrea ;

Inoue, Haruhiro ;

Perri, Vincenzo .

DIGESTIVE AND LIVER DISEASE, 2012, 44 (10) :827-832

[4] Achalasia: Update on the Disease and Its Treatment [J].

Francis, Dawn L. ;

Katzka, David A. .

GASTROENTEROLOGY, 2010, 139 (02) :369-374

[5] Comparison of Perioperative Outcomes Between Peroral Esophageal Myotomy (POEM) and Laparoscopic Heller Myotomy [J].

Hungness, Eric S. ;

Teitelbaum, Ezra N. ;

Santos, Byron F. ;

Arafat, Fahd O. ;

Pandolfino, John E. ;

Kahrilas, Peter J. ;

Soper, Nathaniel J. .

JOURNAL OF GASTROINTESTINAL SURGERY, 2013, 17 (02) :228-235

[6] Peroral endoscopic myotomy (POEM) for esophageal achalasia [J].

Inoue, H. ;

Minami, H. ;

Kobayashi, Y. ;

Sato, Y. ;

Kaga, M. ;

Suzuki, M. ;

Satodate, H. ;

Odaka, N. ;

Itoh, H. ;

Kudo, S. .

ENDOSCOPY, 2010, 42 (04) :265-271

[7] Achalasia: A New Clinically Relevant Classification by High-Resolution Manometry [J].

Pandolfino, John E. ;

Kwiatek, Monika A. ;

Nealis, Thomas ;

Bulsiewicz, William ;

Post, Jennifer ;

Kahrilas, Peter J. .

GASTROENTEROLOGY, 2008, 135 (05) :1526-1533

[8] Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia [J].

Pasricha, P. J. ;

Hawari, R. ;

Ahmed, I. ;

Chen, J. ;

Cotton, P. B. ;

Hawes, R. H. ;

Kalloo, A. N. ;

Kantsevoy, S. V. ;

Gostout, C. J. .

ENDOSCOPY, 2007, 39 (09) :761-764

[9] Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases) [J].

Ren, Zhong ;

Zhong, Yunshi ;

Zhou, Pinghong ;

Xu, Meidong ;

Cai, Mingyan ;

Li, Liang ;

Shi, Qiang ;

Yao, Liqing .

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2012, 26 (11) :3267-3272

[10] Endoscopic therapy for achalasia before Heller myotomy results in worse outcomes than Heller myotomy alone [J].

Smith, CD ;

Stival, A ;

Howell, DL ;

Swafford, V .

ANNALS OF SURGERY, 2006, 243 (05) :579-586

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