Compounds of IL-6 Receptor Complex during Acute Lung Injury

被引：28

作者：

Chepurnova, D. A. ^{[1
]}

Samoilova, E. V. ^{[1
]}

Anisimov, A. A. ^{[1
]}

Verin, A. D. ^{[2
]}

Korotaeva, A. A. ^{[1
]}

机构：

[1] Minist Healthcare Russian Federat, Natl Med Res Ctr Cardiol, Moscow, Russia

[2] Augusta Univ, Augusta, GA USA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 164卷 / 05期

关键词：

inflammation; soluble receptor of IL-6; sgp130; acute lung injury;

D O I：

10.1007/s10517-018-4042-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.

引用

页码：609 / 611

页数：3

共 10 条

[1]

Gonzales JN., 2015, AUSTIN J VASC MED, V2, P1009

[2] The Acute Respiratory Distress Syndrome: From Mechanism to Translation [J].

Han, SeungHye ;

Mallampalli, Rama K. .

JOURNAL OF IMMUNOLOGY, 2015, 194 (03) :855-860

[3] IL-6 as a keystone cytokine in health and disease [J].

Hunter, Christopher A. ;

Jones, Simon A. .

NATURE IMMUNOLOGY, 2015, 16 (05) :448-457

[4] Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses [J].

Jostock, T ;

Müllberg, J ;

Özbek, S ;

Atreya, R ;

Blinn, G ;

Voltz, N ;

Fischer, M ;

Neurath, MF ;

Rose-John, S .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (01) :160-167

[5] The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases [J].

Kallen, KJ .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2002, 1592 (03) :323-343

[6] Lipopolysaccharide-induced acute lung injury in rats: Comparative assessment of intratracheal instillation and aerosol inhalation [J].

Liu, Fangfang ;

Li, Wenli ;

Pauluhn, Juergen ;

Truebel, Hubert ;

Wang, Chen .

TOXICOLOGY, 2013, 304 :158-166

[7] Molecular mechanisms in lipopolysaccharide-induced pulmonary endothelial barrier dysfunction [J].

Liu, Han ;

Yu, Xiu ;

Yu, Sulan ;

Kou, Junping .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 29 (02) :937-946

[8] Animal models of acute lung injury [J].

Matute-Bello, Gustavo ;

Frevert, Charles W. ;

Martin, Thomas R. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2008, 295 (03) :L379-L399

[9] IL-6/IL-6 receptor system and its role in physiological and pathological conditions [J].

Mihara, Masahiko ;

Hashizume, Misato ;

Yoshida, Hiroto ;

Suzuki, Miho ;

Shiina, Masashi .

CLINICAL SCIENCE, 2012, 122 (3-4) :143-159

[10]

[Симбирцев А.С. Simbirtsev A.S.], 2013, [Медицинский академический журнал, Meditsinskii akademicheskii zhurnal], V13, P18

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