Utility of an Immunohistochemical Panel Consisting of Glypican-3, Heat-shock Protein-70, and Glutamine Synthetase in the Distinction of Low-grade Hepatocellular Carcinoma From Hepatocellular Adenoma
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作者:
Lagana, Stephen M.
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Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
Lagana, Stephen M.
[1
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Salomao, Marcela
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Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
Salomao, Marcela
[1
]
Bao, Fei
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Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
Bao, Fei
[1
]
Moreira, Roger K.
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Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
Moreira, Roger K.
[1
]
Lefkowitch, Jay H.
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Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
Lefkowitch, Jay H.
[1
]
Remotti, Helen E.
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Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
Remotti, Helen E.
[1
]
机构:
[1] Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
Background: The pathologic distinction between hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) is sometimes problematic due to histologic overlap between the 2 entities, a problem amplified on small biopsy specimens. Several recently characterized immunohistochemical markers such as glypican-3 (GPC-3), heat-shock protein-70 (HSP-70), and glutamine synthetase (GS) help distinguish dysplastic nodules from HCC. The utility of this panel in the distinction of low-grade hepatocellular carcinoma (LG-HCC) from HCA has not been fully described. Objective: To determine whether the above markers are useful in the distinction of HCCs from HCAs. Design: Tissue microarrays were constructed with 30 LG-HCCs and 18 HCAs. The arrays were stained with the above markers and analyzed with respect to amount and pattern of staining. GPC-3 and HSP-70 were considered positive when 10% of tumor cells showed immunoreactivity. GS was considered positive when 50% of tumor cells showed immunoreactivity. Results: GPC-3 was positive in 13 of 30 LG-HCCs and 0 of 18 adenomas. The sensitivity was 43% and the specificity was 100%. HSP-70 was positive in 14 of 30 LG-HCCs and 0 of 18 adenomas. The sensitivity was 46% and the specificity was 100%. GS was positive in 24 of 30 LG-HCCs and 9 of 18 adenomas. The sensitivity was 80% and the specificity was 50%. Conclusions: GPC-3 and HSP-70 are helpful in separating carcinomas from adenomas. GS is not useful in this clinical context.
机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Abdul-Al, Hala M.
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Makhlouf, Hala R.
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机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Makhlouf, Hala R.
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Wang, Guanghua
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机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Wang, Guanghua
;
Goodman, Zachary D.
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机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
机构:
IRCCS Humanitas Clin Inst, Mol Genet Lab, I-20089 Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Destro, Annarita
;
Seok, Jae Yeon
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Yonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Seok, Jae Yeon
;
Balladore, Emanuela
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机构:
IRCCS Humanitas Clin Inst, Mol Genet Lab, I-20089 Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Balladore, Emanuela
;
Terracciano, Luigi
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机构:
Univ Basel Hosp, Inst Pathol, CH-4031 Basel, SwitzerlandYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Terracciano, Luigi
;
Sanglovanni, Angelo
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机构:
Univ Milan, Div Gastroenterol 1, Fdn IRCCS Maggiore Hosp Policlin Mangiagalli & Re, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Sanglovanni, Angelo
;
Iavarone, Massimo
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机构:
Univ Milan, Div Gastroenterol 1, Fdn IRCCS Maggiore Hosp Policlin Mangiagalli & Re, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Iavarone, Massimo
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Colombo, Massimo
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机构:
Univ Milan, Div Gastroenterol 1, Fdn IRCCS Maggiore Hosp Policlin Mangiagalli & Re, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Colombo, Massimo
;
Jang, Ja June
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机构:
Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Jang, Ja June
;
Yu, Eunsil
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机构:
Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Yu, Eunsil
;
Jin, So Young
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机构:
Soon Chun Hyang Univ, Dept Pathol, Coll Med, Seoul, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Jin, So Young
;
Morenghi, Emanuela
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Humanitas Clin Inst, Dept Clin Res, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Morenghi, Emanuela
;
Park, Young Nyun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Yonsei Univ, Coll Med, Inst Gastroenterol, Brain Korea Project Med Sci 21, Seoul 120749, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Abdul-Al, Hala M.
;
Makhlouf, Hala R.
论文数: 0引用数: 0
h-index: 0
机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Makhlouf, Hala R.
;
Wang, Guanghua
论文数: 0引用数: 0
h-index: 0
机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Wang, Guanghua
;
Goodman, Zachary D.
论文数: 0引用数: 0
h-index: 0
机构:
Armed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
Armed Forces Inst Pathol, Vet Adm Special Reference Lab Pathol, Washington, DC 20306 USAArmed Forces Inst Pathol, Div Hepat Pathol, Washington, DC 20306 USA
机构:
IRCCS Humanitas Clin Inst, Mol Genet Lab, I-20089 Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Destro, Annarita
;
Seok, Jae Yeon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Seok, Jae Yeon
;
Balladore, Emanuela
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Humanitas Clin Inst, Mol Genet Lab, I-20089 Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Balladore, Emanuela
;
Terracciano, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Basel Hosp, Inst Pathol, CH-4031 Basel, SwitzerlandYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Terracciano, Luigi
;
Sanglovanni, Angelo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Div Gastroenterol 1, Fdn IRCCS Maggiore Hosp Policlin Mangiagalli & Re, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Sanglovanni, Angelo
;
Iavarone, Massimo
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h-index: 0
机构:
Univ Milan, Div Gastroenterol 1, Fdn IRCCS Maggiore Hosp Policlin Mangiagalli & Re, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Iavarone, Massimo
;
Colombo, Massimo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Div Gastroenterol 1, Fdn IRCCS Maggiore Hosp Policlin Mangiagalli & Re, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Colombo, Massimo
;
Jang, Ja June
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Jang, Ja June
;
Yu, Eunsil
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Yu, Eunsil
;
Jin, So Young
论文数: 0引用数: 0
h-index: 0
机构:
Soon Chun Hyang Univ, Dept Pathol, Coll Med, Seoul, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Jin, So Young
;
Morenghi, Emanuela
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Humanitas Clin Inst, Dept Clin Res, Milan, ItalyYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Morenghi, Emanuela
;
Park, Young Nyun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea
Yonsei Univ, Coll Med, Inst Gastroenterol, Brain Korea Project Med Sci 21, Seoul 120749, South KoreaYonsei Univ, Coll Med Seoul, Dept Pathol, Seoul 120749, South Korea