Therapeutics strategies against cancer stem cell in breast cancer

被引：47
作者：
Ghasemi, Faezeh [1 ]
Sarabi, Parisa Zia [2 ]
Athari, Seyyed Shamsadin [3 ]
Esmaeilzadeh, Abdolreza [3 ,4 ]
机构：
[1] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran, Iran
[2] Arak Univ Med Sci, Fac Med, Mol & Med Res Ctr, Dept Biotechnol, Arak, Iran
[3] Zanjan Univ Med Sci, Sch Med, Dept Immunol, Zanjan, Iran
[4] Zanjan Univ Med Sci, Canc Gene Therapy Res Ctr CGRC, Zanjan, Iran
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2019年 / 109卷
关键词：
Breast cancer; Cancer stem cell; Notch; Hedgehog; Wnt/b-catenin; PI3K/Akt; NF-kB; BMP and TGF-beta signaling pathways; BONE MORPHOGENETIC PROTEINS; TARGETING CANCER; DRUG-RESISTANCE; THERAPY; PROGRESSION; DIFFERENTIATION; PERSPECTIVES; CHEMOTHERAPY; NETWORKS; CURCUMIN;
D O I：
10.1016/j.biocel.2019.01.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Breast cancer is known as a most prevalent cancer and second deadly cancer, among women worldwide. Due to the high incidence rate of breast cancer and limitations of conventional therapy it seemed essential to look for new targets in cancer cells and directly target them such as target therapy on breast cancer stem cells. In this review we indicate some of therapeutic uses of cancer stem cells in breast cancer. Some strategies are targeting surface specific markers and activated signaling pathways in their microenvironment such as Notch, Hedgehog, Wnt/b-catenin, PI3K/Akt, NF-kB, BMP and TGF-beta and their maintenance and drug resistance, using various miRNAs, enhancement of CSCs apoptosis, differentiation therapy, blocking epithelial to mesenchymal transition and using different natural compounds. Recent studies have shown that cancer stem cells play major roles in target therapy on breast cancer. The new manipulation approaches of cancer stem cells can be used as target therapy of breast cancer that were highlighted for immunotherapy of cancer.
引用
收藏
页码：76 / 81
页数：6
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