Identification of blaOXA-51-like, blaOXA-58, blaDIM-1, and blaVIM Carbapenemase Genes in Hospital Enterobacteriaceae Isolates from Sierra Leone

被引：43

作者：

Leski, Tomasz A. ^{[1
]}

Bangura, Umaru ^{[2
]}

Jimmy, David H. ^{[2
,3
]}

Ansumana, Rashid ^{[2
,4
,5
]}

Lizewski, Stephen E. ^{[1
]}

Li, Robert W. ^{[6
]}

Stenger, David A. ^{[1
]}

Taitt, Chris R. ^{[1
]}

Vora, Gary J. ^{[1
]}

机构：

[1] Naval Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA

[2] Mercy Hosp, Res Lab, Kulanda Town, Bo, Sierra Leone

[3] Njala Univ, Dept Chem, Njala, Sierra Leone

[4] Njala Univ, Inst Environm Management & Qual Control, Njala, Sierra Leone

[5] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

[6] USDA, Anim & Nat Resources Inst, Bovine Funct Genom Lab, Beltsville, MD 20705 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 07期

关键词：

METALLO-BETA-LACTAMASE; MULTIPLEX PCR; ACINETOBACTER; RESISTANCE; EMERGENCE; OUTBREAK; ISABA1; RPOB;

D O I：

10.1128/JCM.00832-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe the results of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of clinical isolates from Mercy Hospital in Bo, Sierra Leone. The most salient findings revealed that (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the bla(DIM-1) gene, which has previously only been reported in The Netherlands, is also circulating in this environment; and (iii) bla(OXA-51-like) and bla(OXA-58) genes, which were thought to reside exclusively in Acinetobacter species, can also be found in members of the Enterobacteriaceae.

引用

页码：2435 / 2438

页数：4

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