Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions

被引:15
作者
Tripathi, Abhilash Kumar [1 ]
David, Aditi [1 ]
Govil, Tanvi [1 ,2 ]
Rauniyar, Shailabh [1 ]
Rathinam, Navanietha Krishnaraj [1 ,3 ]
Goh, Kian Mau [4 ]
Sani, Rajesh Kumar [1 ,2 ,3 ]
机构
[1] South Dakota Sch Mines & Technol, Dept Chem & Biol Engn, Rapid City, SD 57701 USA
[2] Composite & Nanocomposite Adv Mfg Ctr Biomat, Rapid City, SD 57701 USA
[3] South Dakota Sch Mines & Technol, BuG ReMeDEE Consortium, Rapid City, SD 57701 USA
[4] Univ Teknol Malaysia, Fac Sci, Johor Baharu 81310, Malaysia
基金
美国国家科学基金会;
关键词
antineoplastic drug; environment; toxicity; remediation; biodegradation; WASTE-WATER TREATMENT; PERSONAL CARE PRODUCTS; ACTIVATED-SLUDGE TRANSFORMATION; SEPARATE URINE COLLECTION; ANTICANCER DRUGS; CYTOSTATIC DRUGS; MEMBRANE BIOREACTOR; RISK-ASSESSMENT; AQUATIC ENVIRONMENT; TRAMETES-VERSICOLOR;
D O I
10.3390/pr8070747
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The global burden of cancer is on the rise, and as a result, the number of therapeutics administered for chemotherapy is increasing. The occupational exposure, recalcitrant nature and ecotoxicological toxicity of these therapeutics, referred to as antineoplastic (ANP) drugs, have raised concerns about their safe remediation. This review provides an overview of the environmental source of ANPs agents, with emphasis on the currently used remediation approaches. Outpatient excreta, hospital effluents, and waste from pharmaceutical industries are the primary source of ANP waste. The current review describes various biotic and abiotic methods used in the remediation of ANP drugs in the environment. Abiotic methods often generate transformation products (TPs) of unknown toxicity. In this light, obtaining data on the environmental toxicity of ANPs and its TPs is crucial to determine their toxic effect on the ecosystem. We also discuss the biodegradation of ANP drugs using monoculture of fungal and bacterial species, and microbial consortia in sewage treatment plants. The current review effort further explores a safe and sustainable approach for ANP waste treatment to replace existing chemical and oxidation intensive treatment approaches. To conclude, we assess the possibility of integrating biotic and abiotic methods of ANP drug degradation.
引用
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页数:37
相关论文
共 176 条
[1]   CYTOTOXIC DRUGS AND THE AQUATIC ENVIRONMENT - ESTIMATION OF BLEOMYCIN IN RIVER AND WATER SAMPLES [J].
AHERNE, GW ;
HARDCASTLE, A ;
NIELD, AH .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1990, 42 (10) :741-742
[2]  
Aitken M., 2016, IMS I HEALTHC INFORM, V1, P1
[3]   Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species [J].
Amadio, Jessica ;
Murphy, Cormac D. .
BIOTECHNOLOGY LETTERS, 2011, 33 (02) :321-326
[4]   Photocatalytic treatment of wastewater from 5-fluorouracil manufacturing [J].
Anheden, M ;
Goswami, DY ;
Svedberg, G .
JOURNAL OF SOLAR ENERGY ENGINEERING-TRANSACTIONS OF THE ASME, 1996, 118 (01) :2-8
[5]  
[Anonymous], 2015, MICROBIOLOGY, DOI DOI 10.1016/B978-0-12-394626-3.00004-1
[6]  
Ashraf M., 2019, BOVINE SCI A KEY SUS, DOI [10.5772/intechopen.79757, DOI 10.5772/INTECHOPEN.79757]
[7]   In Silico Identification of Bioremediation Potential: Carbamazepine and Other Recalcitrant Personal Care Products [J].
Aukema, Kelly G. ;
Escalante, Diego E. ;
Maltby, Meghan M. ;
Bera, Asim K. ;
Aksan, Alptekin ;
Wackett, Lawrence P. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 51 (02) :880-888
[8]   Effect of cytostatic drug presence on extracellular polymeric substances formation in municipal wastewater treated by membrane bioreactor [J].
Avella, A. C. ;
Delgado, L. F. ;
Goerner, T. ;
Albasi, C. ;
Galmiche, M. ;
de Donato, Ph. .
BIORESOURCE TECHNOLOGY, 2010, 101 (02) :518-526
[9]   Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan [J].
Azuma, Takashi .
APPLIED SCIENCES-BASEL, 2018, 8 (11)
[10]   Occurrence and fate of selected anticancer, antimicrobial, and psychotropic pharmaceuticals in an urban river in a subcatchment of the Yodo River basin, Japan [J].
Azuma, Takashi ;
Ishiuchi, Hirotaka ;
Inoyama, Tomomi ;
Teranishi, Yusuke ;
Yamaoka, Misato ;
Sato, Takaji ;
Mino, Yoshiki .
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2015, 22 (23) :18676-18686