Pluripotent Stem Cells in Clinical Cell Transplantation: Focusing on Induced Pluripotent Stem Cell-Derived RPE Cell Therapy in Age-Related Macular Degeneration

被引：11
作者：
Yang, Yi-Ping [1 ,2 ,3 ]
Hsiao, Yu-Jer [1 ,3 ]
Chang, Kao-Jung [1 ,3 ,4 ]
Foustine, Shania [2 ]
Ko, Yu-Ling [1 ]
Tsai, Yi-Ching [1 ]
Tai, Hsiao-Yun [1 ]
Ko, Yu-Chieh [5 ]
Chiou, Shih-Hwa [1 ,2 ,3 ,5 ,6 ]
Lin, Tai-Chi [3 ,5 ]
Chen, Shih-Jen [5 ]
Chien, Yueh [1 ,2 ,3 ]
Hwang, De-Kuang [3 ,4 ,5 ]
机构：
[1] Taipei Vet Gen Hosp, Dept Med Res, Taipei 112201, Taiwan
[2] Natl Yang Ming Chiao Tung Univ, Coll Med, Inst Pharmacol, Taipei 112304, Taiwan
[3] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei 112304, Taiwan
[4] Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Taipei 112304, Taiwan
[5] Taipei Vet Gen Hosp, Dept Ophthalmol, Taipei 112201, Taiwan
[6] Acad Sinica, Genom Res Ctr, Taipei 115201, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 22期
关键词：
pluripotent stem cells; embryonic stem cells; induced pluripotent stem cell; clinical trials; retinal pigment epithelial cells; age-related macular degeneration; cell transplantation; RETINAL-PIGMENT EPITHELIUM; MODELS; MONKEY; MOUSE;
D O I：
10.3390/ijms232213794
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Human pluripotent stem cells (PSCs), including both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represent valuable cell sources to replace diseased or injured tissues in regenerative medicine. iPSCs exhibit the potential for indefinite self-renewal and differentiation into various cell types and can be reprogrammed from somatic tissue that can be easily obtained, paving the way for cell therapy, regenerative medicine, and personalized medicine. Cell therapies using various iPSC-derived cell types are now evolving rapidly for the treatment of clinical diseases, including Parkinson's disease, hematological diseases, cardiomyopathy, osteoarthritis, and retinal diseases. Since the first interventional clinical trial with autologous iPSC-derived retinal pigment epithelial cells (RPEs) for the treatment of age-related macular degeneration (AMD) was accomplished in Japan, several preclinical trials using iPSC suspensions or monolayers have been launched, or are ongoing or completed. The evolution and generation of human leukocyte antigen (HLA)-universal iPSCs may facilitate the clinical application of iPSC-based therapies. Thus, iPSCs hold great promise in the treatment of multiple retinal diseases. The efficacy and adverse effects of iPSC-based retinal therapies should be carefully assessed in ongoing and further clinical trials.
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页数：13
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