Evaluation of the Effect of Treatment of Latent Tuberculosis Infection on QuantiFERON-TB Gold Assay Results

被引：20

作者：

Pollock, Nira R. ^{[1
]}

Kashino, Suely S.

Napolitano, Danielle R.

Sloutsky, Alex ^{[2
]}

Joshi, Swati ^{[2
]}

Guillet, Jasmine ^{[2
]}

Wong, Michael ^{[1
]}

Nardell, Edward ^{[3
]}

Campos-Neto, Antonio ^{[4
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA

[2] Massachusetts State Lab Inst, Boston, MA USA

[3] Brigham & Womens Hosp, Div Social Med & Hlth Inequal, Boston, MA 02115 USA

[4] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2009年 / 30卷 / 04期

关键词：

INTERFERON-GAMMA RESPONSES; MYCOBACTERIUM-TUBERCULOSIS; CELL RESPONSES;

D O I：

10.1086/596606

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To evaluate the utility of the QuantiFERON-TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON-TB Gold positive, and cellular proliferation assays revealed persistently strong purified protein derivative responses. These results do not support the use of the QuantiFERON-TB Gold assay to monitor therapy.

引用

页码：392 / 395

页数：4

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