Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery

被引：145

作者：

Raemdonck, Koen ^{[1
]}

Braeckmans, Kevin ^{[1
,2
]}

Demeester, Jo ^{[1
]}

De Smedt, Stefaan C. ^{[1
]}

机构：

[1] Univ Ghent, Fac Pharmaceut Sci, Lab Gen Biochem & Phys Pharm, Ghent Res Grp Nanomed, B-9000 Ghent, Belgium

[2] Univ Ghent, Ctr Nano & Biophoton, B-9000 Ghent, Belgium

来源：

CHEMICAL SOCIETY REVIEWS | 2014年 / 43卷 / 01期

关键词：

MESOPOROUS SILICA NANOPARTICLES; SMALL INTERFERING RNA; NUCLEIC-ACID DELIVERY; SUPRAMOLECULAR BIOVECTORS SMBV; BIODEGRADABLE DEXTRAN NANOGELS; COATED PLGA NANOPARTICLES; SIRNA DELIVERY; TARGETED DELIVERY; IN-VITRO; PHOTOCHEMICAL INTERNALIZATION;

D O I：

10.1039/c3cs60299k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.

引用

页码：444 / 472

页数：29

共 247 条

[81] Nanoparticle-based combination therapy toward overcoming drug resistance in cancer [J].