'Omics' biomarkers associated with chronic low back pain: protocol of a retrospective longitudinal study

被引：16

作者：

Allegri, Massimo ^{[1
,2
]}

De Gregori, Manuela ^{[3
]}

Minella, Cristina E. ^{[3
]}

Klersy, Catherine ^{[4
]}

Wang, Wei ^{[5
]}

Sim, Moira ^{[5
]}

Gieger, Christian ^{[6
,7
]}

Manz, Judith ^{[6
,7
]}

Pemberton, Iain K. ^{[8
]}

MacDougall, Jane ^{[8
]}

Williams, Frances M. K. ^{[9
]}

Van Zundert, Jan ^{[10
]}

Buyse, Klaas ^{[10
]}

Lauc, Gordan ^{[11
]}

Gudelj, Ivan ^{[11
]}

Primorac, Dragan ^{[12
,13
,14
,15
,16
]}

Skelin, Andrea ^{[11
,12
]}

Aulchenko, Yurii S. ^{[17
]}

Karssen, Lennart C. ^{[17
]}

Kapural, Leonardo ^{[18
]}

Rauck, Richard ^{[18
]}

Fanelli, Guido ^{[1
,2
]}

机构：

[1] Univ Parma, Dept Surg Sci, Parma, Italy

[2] Azienda Osped Univ Parma, Anesthesia Intens Care & Pain Therapy Serv, Parma, Italy

[3] Fdn IRCCS Policlin San Matteo, Emergency Dept, Anesthesia Intens Care & Pain Therapy, Pavia, Italy

[4] Fdn IRCCS Policlin San Matteo, Serv Biometry & Stat, Res Dept, Pavia, Italy

[5] Edith Cowan Univ, Sch Med & Hlth Sci, Perth, WA, Australia

[6] German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Neuherberg, Germany

[7] German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 2, Neuherberg, Germany

[8] IP Res Consulting SAS, Photeomix, Noisy Le Grand, France

[9] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

[10] Ziekenhuis Oost Limburg, Crit Care & Multidisciplinary Pain Ctr, Dept Anesthesiol, Genk, Belgium

[11] Genos Glycosci Res Lab, Zagreb, Croatia

[12] St Catherine Specialty Hosp, Zabok, Croatia

[13] Penn State Univ, Eberly Coll Sci, State Coll, PA USA

[14] Univ Osijek, Fac Med, Osijek, Croatia

[15] Univ Split, Sch Med, Split, Croatia

[16] Childrens Hosp Srebrnjak, Zagreb, Croatia

[17] PolyOmica, Groningen, Netherlands

[18] Carolinas Pain Inst, Winston Salem, NC USA

来源：

BMJ OPEN | 2016年 / 6卷 / 10期

关键词：

LUMBAR DISC DEGENERATION; DISEASE; HERITABILITY; METAANALYSIS; MECHANISMS; PROVIDE; BURDEN;

D O I：

10.1136/bmjopen-2016-012070

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molecular pathologies and interaction with psychosocial factors that leads to a range of clinical manifestations. There is still much to understand in the underlying pathological processes and the non-psychosocial factors which account for differences in outcomes. Biomarkers that may be objectively used for diagnosis and personalised, targeted and cost-effective treatment are still lacking. Therefore, any data that may be obtained at the '-omics' level (glycomics, Activomics and genome-wide association studies-GWAS) may be helpful to use as dynamic biomarkers for elucidating CLBP pathogenesis and may ultimately provide prognostic information too. By means of a retrospective, observational, case-cohort, multicentre study, we aim to investigate new promising biomarkers potentially able to solve some of the issues related to CLBP. Methods and analysis: The study follows a two-phase, 1: 2 case-control model. A total of 12 000 individuals (4000 cases and 8000 controls) will be enrolled; clinical data will be registered, with particular attention to pain characteristics and outcomes of pain treatments. Blood samples will be collected to perform -omics studies. The primary objective is to recognise genetic variants associated with CLBP; secondary objectives are to study glycomics and Activomics profiles associated with CLBP. Ethics and dissemination: The study is part of the PainOMICS project funded by European Community in the Seventh Framework Programme. The study has been approved from competent ethical bodies and copies of approvals were provided to the European Commission before starting the study. Results of the study will be reviewed by the Scientific Board and Ethical Committee of the PainOMICS Consortium. The scientific results will be disseminated through peer-reviewed journals.

引用

页数：8

共 37 条

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