Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

被引：232

作者：

Haussler, Mark R. ^{[1
]}

Haussler, Carol A. ^{[1
]}

Bartik, Leonid ^{[2
]}

Whitfield, G. Kerr ^{[1
]}

Hsieh, Jui-Cheng ^{[1
]}

Slater, Stephanie

Jurutka, Peter W. ^{[3
]}

机构：

[1] Univ Arizona, Coll Med, Dept Basic Med Sci, Phoenix, AZ 85004 USA

[2] Johns Hopkins Univ, Baltimore, MD USA

[3] Arizona State Univ W Campus, Dept Integrated Nat Sci, Glendale, AR USA

来源：

NUTRITION REVIEWS | 2008年 / 66卷 / 10期

关键词：

1,25-dihydroxyvitamin D-3 hormone; bone mineral; colon cancer; hair cycling; phosphorus;

D O I：

10.1111/j.1753-4887.2008.00093.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The human vitamin D receptor (VDR) is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts with the corepressor hairless (Hr) to control hair cycling, an action independent of the endocrine VDR ligand, 1,25-dihydroxyvitamin D-3. We report novel dietary ligands for VDR including curcumin, gamma-tocotrienol, and essential fatty acid derivatives that likely play a role in the bioactions of VDR. (C) 2008 International Life Sciences Institute.

引用

页码：S98 / S112

页数：15

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