The Role of IFN-alpha in Experimental and Clinical Uveitis

被引：2
作者：
Liu, Xiaoli [1 ]
Diedrichs-Moehring, Maria [1 ]
Wildner, Gerhild [1 ]
机构：
[1] Klinikum Univ Munchen, Dept Ophthalmol, Immunobiol Sect, Mathildenstr 8, D-80336 Munich, Germany
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2019年 / 27卷 / 01期
关键词：
NK cells; rat experimental autoimmune uveitis; regulatory T cells; Th1; Th17; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; REGULATORY T-CELLS; ENDOTHELIAL GROWTH-FACTOR; HUMAN RECOMBINANT INTERFERON-ALPHA-2A; IL-1 RECEPTOR ANTAGONIST; BEHCETS-DISEASE PATIENTS; LONG-TERM EFFICACY; MONONUCLEAR-CELLS; DENDRITIC CELLS; VIRUS-INFECTION;
D O I：
10.1080/09273948.2017.1298822
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: IFN-alpha is the only treatment capable of inducing long-term remission in some patients with ocular Behcet's disease. In this review, we focus on immune mechanisms of IFN-alpha in animal models and patients and compare the outcome of different clinical studies. Methods: Review of literature using PubMed and Google and original data from rat models with monophasic/chronic or relapsing experimental autoimmune uveitis treated with IFN-alpha. Results: The role of IFN-alpha and its effect on various cell types were investigated, in some cases with contradictory results. Some patients respond very well to IFN-alpha treatment, while others are non-responders, which was reflected in the uveitis rat models: relapsing uveitis was ameliorated, the monophasic/chronic disease even aggravated. Conclusions: Despite intensive investigations in patients and animal models, the immune mechanisms explaining the therapeutic effect of IFN-alpha in ocular Behcet's disease are not yet fully understood and need further investigation.
引用
收藏
页码：23 / 33
页数：11
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