Synthesis of cyclam-capped β-cyclodextrin-bonded silica particles for use as chiral stationary Phases in capillary electrochromatography

被引：24

作者：

Gong, YH

Xue, GP

Xiang, YQ

Bradshaw, JS

Lee, ML

Lee, HK

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 13期

关键词：

chiral stationary phase; enantiomeric separation; cyclam; crown ether; beta-cyclodextrin; capillary electrochromatography;

D O I：

10.1016/S0040-4039(02)00286-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Cyclodextrin (beta-CD) was anchored onto silica particles at its C(2) position, derivatized primarily at the C(6) position by treatment with bromoacetyl bromide, and finally reacted with two types of cyclams to form cyclam-capped beta-CD-bonded silica particles. When used as chiral stationary phases in capillary electrochromatography, these novel bonded silica particles exhibited excellent enantioselectivities for chiral separations. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2463 / 2466

页数：4

共 14 条

[1]

AHUJA S, 2000, CHIRAL SEPARATIONS C, P99

[2] Mechanism of capillary electrophoresis enantioseparations using a combination of an achiral crown ether plus cyclodextrins [J].