Highly Enantio- and Diastereoselective Mannich Reactions of Chiral Ni(II) Glycinates with Amino Sulfones. Efficient Asymmetric Synthesis of Aromatic α,β-Diamino Acids

被引：46

作者：

Wang, Jiang ^{[1
]}

Shi, Ting ^{[1
]}

Deng, Guanghui ^{[1
]}

Jiang, Hualiang ^{[1
]}

Liu, Hong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr,Grad Sch, State Key Lab Drug Res,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 21期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/jo8019169

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes a practical, enantio- and diastereoselective Mannich reaction between a chiral Ni(II) complex of glycine I and a.-amino sulfones 2, involving the creation of a carbon-carbon bond and two stereogenic centers in a single operation; it represents an attractive route to the synthesis alpha,beta-diamino acids.

引用

收藏

页码：8563 / 8570

页数：8

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