Evolutionary Dynamics of Genes and Environment in Cancer Development Evolution of Cancer

被引：0

作者：

Breivik, Jarle ^{[1
]}

机构：

[1] Univ Oslo, Fac Med, Inst Basic Med Sci, N-0315 Oslo, Norway

来源：

EVOLUTION FROM CELLULAR TO SOCIAL SCALES | 2008年

关键词：

Cancer; evolution; genetics;

D O I：

10.1007/978-1-4020-8761-5_10

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cancer development involves dynamic interplay between genes and environment, and is increasingly understood as an evolutionary process within the body of an organism. Concurrently, human predisposition for cancer may also be regarded in an evolutionary perspective, shaped by interaction of genes and environment through the generations. We have developed a theoretical model that combines this somatic and germline evolution of cancer. Key predictions have been tested and confirmed by independent studies and the model has general implications for the understanding of cancer.

引用

页码：143 / 147

页数：5

共 16 条

[1]

Arends JW, 2000, J PATHOL, V190, P412

[2] Carcinogen-specific induction of genetic instability [J].

Bardelli, A ;

Cahill, CP ;

Lederer, G ;

Speicher, MR ;

Kinzler, KW ;

Vogelstein, B ;

Lengauer, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) :5770-5775

[3] Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis [J].

Breivik, J ;

Gaudernack, G .

SEMINARS IN CANCER BIOLOGY, 1999, 9 (04) :245-254

[4] The evolutionary origin of genetic instability in cancer development [J].

Breivik, J .

SEMINARS IN CANCER BIOLOGY, 2005, 15 (01) :51-60

[5] Resolving the evolutionary paradox of genetic instability: a cost-benefit analysis of DNA repair in changing environments [J].

Breivik, J ;

Gaudernack, G .

FEBS LETTERS, 2004, 563 (1-3) :7-12

[6] Carcinogenesis and natural selection: A new perspective to the genetics and epigenetics of colorectal cancer [J].

Breivik, J ;

Gaudernack, G .

ADVANCES IN CANCER RESEARCH, VOL 76, 1999, 76 :187-+

[7] Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development [J].

Breivik, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) :5379-5381

[8] Commentary: Cancer-evolution within [J].

Breivik, Jarle .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2006, 35 (05) :1161-1162

[9] Genetic instability and darwinian selection in tumours (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999) [J].

Cahill, DP ;

Kinzler, KW ;

Vogelstein, B ;

Lengauer, C .

TRENDS IN CELL BIOLOGY, 1999, 9 (12) :M57-M60

[10]

Darwin C., 1859, ORIGIN SPECIES MEANS, DOI [DOI 10.5962/BHL.TITLE.82303, 10.5962/bhl.title.82303]

← 1 2 →