RNA-directed DNA methylation regulates parental genomic imprinting at several loci in Arabidopsis

被引:67
|
作者
Thiet Minh Vu [1 ,2 ]
Nakamura, Miyuki [3 ]
Calarco, Joseph P. [4 ]
Susaki, Daichi [5 ]
Lim, Pei Qi [1 ]
Kinoshita, Tetsu [3 ]
Higashiyama, Tetsuya [5 ,6 ]
Martienssen, Robert A. [4 ]
Berger, Frederic [1 ,2 ]
机构
[1] Natl Univ Singapore, Temasek Life Sci Lab, Singapore 117604, Singapore
[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
[3] Nara Inst Sci & Technol, Ikoma, Nara 6300192, Japan
[4] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[5] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan
[6] Nagoya Univ, JST ERATO Higashiyama Live Holon Project, Chikusa Ku, Nagoya, Aichi 4648602, Japan
来源
DEVELOPMENT | 2013年 / 140卷 / 14期
基金
美国国家科学基金会; 日本学术振兴会;
关键词
Arabidopsis; Seed; Imprinting; Endosperm; RdDM; DNA methylation; GENE-EXPRESSION; EPIGENETIC INHERITANCE; SEED DEVELOPMENT; MAIZE ENDOSPERM; THALIANA; PLANT; EVOLUTION; SIRNA; IV; METHYLTRANSFERASES;
D O I
10.1242/dev.092981
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In mammals and plants, parental genomic imprinting restricts the expression of specific loci to one parental allele. Imprinting in mammals relies on sex-dependent de novo deposition of DNA methylation during gametogenesis but a comparable mechanism was not shown in plants. Rather, paternal silencing by the maintenance DNA methyltransferase 1 (MET1) and maternal activation by the DNA demethylase DEMETER (DME) cause maternal expression. However, genome-wide studies suggested other DNA methylation-dependent imprinting mechanisms. Here, we show that de novo RNA-directed DNA methylation (RdDM) regulates imprinting at specific loci expressed in endosperm. RdDM in somatic tissues is required to silence expression of the paternal allele. By contrast, the repression of RdDM in female gametes participates with or without DME requirement in the activation of the maternal allele. The contrasted activity of DNA methylation between male and female gametes appears sufficient to prime imprinted maternal expression. After fertilization, MET1 maintains differential expression between the parental alleles. RdDM depends on small interfering RNAs (siRNAs). The involvement of RdDM in imprinting supports the idea that sources of siRNAs such as transposons and de novo DNA methylation were recruited in a convergent manner in plants and mammals in the evolutionary process leading to selection of imprinted loci.
引用
收藏
页码:2953 / 2960
页数:8
相关论文
共 50 条
  • [41] Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis
    Liu, Zhang-Wei
    Zhou, Jin-Xing
    Huang, Huan-Wei
    Li, Yong-Qiang
    Shao, Chang-Rong
    Li, Lin
    Cai, Tao
    Chen, She
    He, Xin-Jian
    PLOS GENETICS, 2016, 12 (05):
  • [42] Protocol: a beginner's guide to the analysis of RNA-directed DNA methylation in plants
    Zhang, Huiming
    Tang, Kai
    Wang, Bangshing
    Duan, Cheng-Guo
    Lang, Zhaobo
    Zhu, Jian-Kang
    PLANT METHODS, 2014, 10
  • [43] Reinforcement of CHH methylation through RNA-directed DNA methylation ensures sexual reproduction in rice
    Wang, Lili
    Zheng, Kezhi
    Zeng, Longjun
    Xu, Dachao
    Zhu, Tianxin
    Yin, Yumeng
    Zhan, Huadong
    Wu, Yufeng
    Yang, Dong-Lei
    PLANT PHYSIOLOGY, 2022, 188 (02) : 1189 - 1209
  • [44] RNA-directed DNA methylation efficiency depends on trigger and target sequence identity
    Dalakouras, Athanasios
    Dadami, Elena
    Wassenegger, Michele
    Krczal, Gabi
    Wassenegger, Michael
    PLANT JOURNAL, 2016, 87 (02) : 202 - 214
  • [45] Angiosperms Are Unique among Land Plant Lineages in the Occurrence of Key Genes in the RNA-Directed DNA Methylation (RdDM) Pathway
    Ma, Lu
    Hatlen, Andrea
    Kelly, Laura J.
    Becher, Hannes
    Wang, Wencai
    Kovarik, Ales
    Leitch, Ilia J.
    Leitch, Andrew R.
    GENOME BIOLOGY AND EVOLUTION, 2015, 7 (09): : 2648 - 2662
  • [46] Argonaute 4 as an Effector Protein in RNA-Directed DNA Methylation in Human Cells
    Chalertpet, Kanwalat
    Pin-on, Piyapat
    Aporntewan, Chatchawit
    Patchsung, Maturada
    Ingrungruanglert, Praewphan
    Israsena, Nipan
    Mutirangura, Apiwat
    FRONTIERS IN GENETICS, 2019, 10
  • [47] FVE promotes RNA-directed DNA methylation by facilitating the association of RNA polymerase V with chromatin
    Zhou, Jin-Xing
    Du, Ping
    Liu, Zhang-Wei
    Feng, Chao
    Cai, Xue-Wei
    He, Xin-Jian
    PLANT JOURNAL, 2021, 107 (02) : 467 - 479
  • [48] Maize decrease in DNA methylation 1 targets RNA-directed DNA methylation on active chromatin
    Long, Jincheng
    Liu, Jinghan
    Xia, Aiai
    Springer, Nathan M.
    He, Yan
    PLANT CELL, 2021, 33 (07) : 2183 - 2196
  • [49] Chloroplast development and genomes uncoupled signaling are independent of the RNA-directed DNA methylation pathway
    Wang, Liangsheng
    Leister, Dario
    Kleine, Tatjana
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [50] Exogenous Promoter Triggers APETALA3 Silencing through RNA-Directed DNA Methylation Pathway in Arabidopsis
    Wang, Benqi
    Liu, Jie
    Chu, Lei
    Jing, Xue
    Wang, Huadong
    Guo, Jian
    Yi, Bin
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (18)