RNA-directed DNA methylation regulates parental genomic imprinting at several loci in Arabidopsis

被引:67
|
作者
Thiet Minh Vu [1 ,2 ]
Nakamura, Miyuki [3 ]
Calarco, Joseph P. [4 ]
Susaki, Daichi [5 ]
Lim, Pei Qi [1 ]
Kinoshita, Tetsu [3 ]
Higashiyama, Tetsuya [5 ,6 ]
Martienssen, Robert A. [4 ]
Berger, Frederic [1 ,2 ]
机构
[1] Natl Univ Singapore, Temasek Life Sci Lab, Singapore 117604, Singapore
[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
[3] Nara Inst Sci & Technol, Ikoma, Nara 6300192, Japan
[4] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[5] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan
[6] Nagoya Univ, JST ERATO Higashiyama Live Holon Project, Chikusa Ku, Nagoya, Aichi 4648602, Japan
来源
DEVELOPMENT | 2013年 / 140卷 / 14期
基金
美国国家科学基金会; 日本学术振兴会;
关键词
Arabidopsis; Seed; Imprinting; Endosperm; RdDM; DNA methylation; GENE-EXPRESSION; EPIGENETIC INHERITANCE; SEED DEVELOPMENT; MAIZE ENDOSPERM; THALIANA; PLANT; EVOLUTION; SIRNA; IV; METHYLTRANSFERASES;
D O I
10.1242/dev.092981
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In mammals and plants, parental genomic imprinting restricts the expression of specific loci to one parental allele. Imprinting in mammals relies on sex-dependent de novo deposition of DNA methylation during gametogenesis but a comparable mechanism was not shown in plants. Rather, paternal silencing by the maintenance DNA methyltransferase 1 (MET1) and maternal activation by the DNA demethylase DEMETER (DME) cause maternal expression. However, genome-wide studies suggested other DNA methylation-dependent imprinting mechanisms. Here, we show that de novo RNA-directed DNA methylation (RdDM) regulates imprinting at specific loci expressed in endosperm. RdDM in somatic tissues is required to silence expression of the paternal allele. By contrast, the repression of RdDM in female gametes participates with or without DME requirement in the activation of the maternal allele. The contrasted activity of DNA methylation between male and female gametes appears sufficient to prime imprinted maternal expression. After fertilization, MET1 maintains differential expression between the parental alleles. RdDM depends on small interfering RNAs (siRNAs). The involvement of RdDM in imprinting supports the idea that sources of siRNAs such as transposons and de novo DNA methylation were recruited in a convergent manner in plants and mammals in the evolutionary process leading to selection of imprinted loci.
引用
收藏
页码:2953 / 2960
页数:8
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