Progression of retinopathy in insulin-treated type 2 diabetic patients

被引：37
作者：
Henricsson, M
Berntorp, K
Fernlund, P
Sundkvist, G
机构：
[1] Malmo Univ Hosp, Dept Ophthalmol, Malmo, Sweden
[2] Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden
[3] Malmo Univ Hosp, Dept Clin Chem, Malmo, Sweden
来源：
DIABETES CARE | 2002年 / 25卷 / 02期
关键词：
D O I：
10.2337/diacare.25.2.381
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
OBJECTIVE- To study the progression of retinopathy 3 years after initiation of insulin therapy. RESEARCH DESIGN AND METHODS- In a prospective, observational case-control study, 42 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, 24, and 36 months after change to insulin therapy. Retinopathy was graded based on fundus photographs using the Wisconsin scale; HbA(1c) and IGF-1 were measured. RESULTS - During the observation period of 3 years, 26 patients progressed in the retinopathy scale; 11 patients progressed at least three levels. After 3 years of insulin therapy HbA(1c) and IGF-1 were significantly lower than at baseline. Progression of retinopathy greater than or equal to three levels was related to high IGF-1 levels. CONCLUSIONS- A relationship was found between high IGF-1 levels at 3 years and progression of retinopathy in type 2 diabetic patients.
引用
收藏
页码：381 / 385
页数：5
相关论文
共 28 条
[1]   Evidence that upregulation of serum IGF-1 concentration can trigger acceleration of diabetic retinopathy [J].
Chantelau, E .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1998, 82 (07) :725-730
[2]   Elevation of serum IGF-1 rather than sex steroids precedes proliferative diabetic retinopathy in Mauriac's syndrome [J].
Chantelau, E ;
Seppel, T ;
Althaus, C ;
Schonau, E .
HORMONE RESEARCH, 1997, 48 (03) :131-134
[3]   RELATIONSHIPS BETWEEN DIABETES DURATION, METABOLIC CONTROL AND BETA-CELL FUNCTION IN A REPRESENTATIVE POPULATION OF TYPE-2 DIABETIC-PATIENTS IN SWEDEN [J].
CLAUSON, P ;
LINNARSSON, R ;
GOTTSATER, A ;
SUNDKVIST, G ;
GRILL, V .
DIABETIC MEDICINE, 1994, 11 (08) :794-801
[4]   Insulin-like growth factor-I and insulin-like growth factor binding protein-1 in a representative population of type 2 diabetic patients in Sweden [J].
Clauson, PG ;
Brismar, K ;
Hall, K ;
Linnarsson, R ;
Grill, V .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1998, 58 (04) :353-360
[5]   RAPID TIGHTENING OF BLOOD-GLUCOSE CONTROL LEADS TO TRANSIENT DETERIORATION OF RETINOPATHY IN INSULIN DEPENDENT DIABETES-MELLITUS - THE OSLO STUDY [J].
DAHLJORGENSEN, K ;
BRINCHMANNHANSEN, O ;
HANSSEN, KF ;
SANDVIK, L ;
AAGENAES, O .
BRITISH MEDICAL JOURNAL, 1985, 290 (6471) :811-815
[6]  
Diabet Contr Complicat Trial Res Grp, 1998, ARCH OPHTHALMOL-CHIC, V116, P874
[7]   PANCREATIC BETA-CELL FUNCTION EVALUATED BY INTRAVENOUS GLUCOSE AND GLUCAGON STIMULATION - A COMPARISON BETWEEN INSULIN AND C-PEPTIDE TO MEASURE INSULIN-SECRETION [J].
GOTTSATER, A ;
LANDINOLSSON, M ;
FERNLUND, P ;
GULLBERG, B ;
LERNMARK, A ;
SUNDKVIST, G .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1992, 52 (07) :631-639
[8]   The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy - A randomized controlled study [J].
Grant, MB ;
Mames, RN ;
Fitzgerald, C ;
Hazariwala, KM ;
Cooper-DeHoff, R ;
Caballero, S ;
Estes, KS .
DIABETES CARE, 2000, 23 (04) :504-509
[9]   INHIBITION OF IGF-I AND B-FGF STIMULATED GROWTH OF HUMAN RETINAL ENDOTHELIAL-CELLS BY THE SOMATOSTATIN ANALOG, OCTREOTIDE - A POTENTIAL TREATMENT FOR OCULAR NEOVASCULARIZATION [J].
GRANT, MB ;
CABALLERO, S ;
MILLARD, WJ .
REGULATORY PEPTIDES, 1993, 48 (1-2) :267-278
[10]  
Henry B, 1999, STAND MAG, V1, P22
123