The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy

被引：73

作者：

Paucek, Richard D. ^{[1
,2
]}

Baltimore, David ^{[1
,3
,4
]}

Li, Guideng ^{[1
,5
,6
,7
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, PICI, Los Angeles, CA 90024 USA

[4] CALTECH, Pasadena, CA 91125 USA

[5] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing, Peoples R China

[6] Peking Union Med Coll, Beijing, Peoples R China

[7] Suzhou Inst Syst Med, Suzhou, Peoples R China

来源：

TRENDS IN IMMUNOLOGY | 2019年 / 40卷 / 04期

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; CD8; T-CELLS; CANCER REGRESSION; ANTITUMOR-ACTIVITY; ANTIGEN DISCOVERY; PD-1; BLOCKADE; CLASS-I; RECEPTORS; TARGET; LEUKEMIA;

D O I：

10.1016/j.it.2019.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunotherapy treatments harnessing the patient's immune system herald a new era of personalized medicine, offering hope for curative responses in patients with serious illnesses. Cell-mediated immunity can eliminate cancer cells and provide durable remissions. This often relies on repurposing cytotoxic T cell activity through modified T cell receptors or chimeric antigen receptors. Furthermore, synthetic biology has expanded the cell engineering toolkit to provide immune cells with more functionality, including disease targeting, potency, and safety. We focus on T cell-based immunotherapy, highlighting discoveries of genetic engineering and therapeutic use. We also examine emerging paths that could be undertaken to improve this novel class of drugs, and discuss the challenges of toxicities as well as other limitations of cellular immunotherapy.

引用

页码：292 / 309

页数：18

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