Protein aggregates and dementia: is there a common toxicity?

被引：57

作者：

Lovestone, S ^{[1
]}

McLoughlin, DM ^{[1
]}

机构：

[1] Inst Psychiat, Old Age Psychiat Sect, London SE5 8AF, England

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2002年 / 72卷 / 02期

关键词：

D O I：

10.1136/jnnp.72.2.152

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)-beta-amyloid peptide and tau-but also considers other proteins in this disorder and in less common but equally devastating diseases.

引用

页码：152 / 161

页数：10

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