VALIDATION OF DELAYED GADOLINIUM-ENHANCED MAGNETIC RESONANCE IMAGING OF CARTILAGE AND T2 MAPPING FOR QUANTIFYING DISTAL METACARPUS/METATARSUS CARTILAGE THICKNESS IN THOROUGHBRED RACEHORSES

被引:13
作者
Carstens, Ann [1 ]
Kirberger, Robert M. [1 ]
Dahlberg, Leif E. [4 ]
Prozesky, Leon [2 ]
Fletcher, Lizelle [3 ]
Lammentausta, Eveliina [4 ,5 ]
机构
[1] Univ Pretoria, Sect Diagnost Imaging, Dept Compan Anim Clin Studies, ZA-0002 Pretoria, South Africa
[2] Univ Pretoria, Dept Pathol, Fac Vet Sci, ZA-0002 Pretoria, South Africa
[3] Univ Pretoria, Dept Stat, ZA-0002 Pretoria, South Africa
[4] Malmo Univ Hosp, Dept Orthopaed, Malmo, Sweden
[5] Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland
基金
新加坡国家研究基金会;
关键词
cartilage; dGEMRIC; horse; MRI; T2; mapping; validation; GUINEA-PIG MODEL; ARTICULAR-CARTILAGE; QUANTITATIVE ASSESSMENT; KNEE CARTILAGE; SUBCHONDRAL BONE; MRI; REPRODUCIBILITY; HORSES; VOLUME; QUANTIFICATION;
D O I
10.1111/vru.12002
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The purpose of this study was to determine whether delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 (Mc3/Mt3) of Thoroughbred racehorses. Twenty-four Mc3/Mt3 cadaver specimens were acquired from six healthy racehorses. Cartilage thickness was measured from postintra-articular Gd-DTPA2 images acquired using short tau inversion recovery (STIR), and proton density weighted (PDw) sequences, and compared with cartilage thickness measured from corresponding histologic images. Two observers performed each histologic measurement twice at three different sites, with measurement times spaced at least 5 days apart. Histologic cartilage thickness was measured at each of the three sites from the articular surface to the bonecartilage interface, and from the articular surface to the mineralized cartilage interface (tidemark). Intra-observer repeatability was good to moderate for dGEMRIC where Mc3/Mt3 cartilage was not in contact with the proximal phalanx. Where the Mc3/Mt3 cartilage was in contact with the proximal phalanx cartilage, dGEMRIC STIR and T2 mapping PDw cartilage thicknesses of Mc3/Mt3 could not be measured reliably. When measured from the articular surface to the bonecartilage interface, histologic cartilage thickness did not differ from STIR or PDw cartilage thickness at the site where the Mc3/Mt3 cartilage surface was separated from the proximal phalanx cartilage (P > 0.05). Findings indicated that dGEMRIC STIR and T2 mapping PDw are accurate techniques for measuring Mc3/Mt3 cartilage thickness at locations where the cartilage is not in direct contact with the proximal phalanx cartilage.
引用
收藏
页码:139 / 148
页数:10
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