A Model for the Design and Construction of a Resource for the Validation of Prognostic Prostate Cancer Biomarkers: The Canary Prostate Cancer Tissue Microarray

被引：20

作者：

Hawley, Sarah ^{[1
]}

Fazli, Ladan ^{[7
]}

McKenney, Jesse K. ^{[8
]}

Simko, Jeff ^{[2
,3
,5
]}

Troyer, Dean ^{[9
,10
,12
]}

Nicolas, Marlo ^{[12
]}

Newcomb, Lisa F. ^{[14
]}

Cowan, Janet E. ^{[2
]}

Crouch, Luis ^{[15
]}

Ferrari, Michelle ^{[6
]}

Hernandez, Javier ^{[13
]}

Hurtado-Coll, Antonio ^{[7
]}

Kuchinsky, Kyle ^{[2
]}

Liew, Janet ^{[7
]}

Mendez-Meza, Rosario ^{[12
]}

Smith, Elizabeth ^{[9
,10
]}

Tenggara, Imelda ^{[2
]}

Zhang, Xiaotun ^{[14
]}

Carroll, Peter R. ^{[3
,5
]}

Chan, June M. ^{[3
,4
,5
]}

Gleave, Martin ^{[7
]}

Lance, Raymond ^{[11
]}

Lin, Daniel W. ^{[14
]}

Nelson, Peter S. ^{[16
]}

Thompson, Ian M. ^{[13
]}

Feng, Ziding ^{[17
]}

True, Lawrence D. ^{[18
]}

Brooks, James D. ^{[6
]}

机构：

[1] Canary Fdn, Palo Alto, CA 94304 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[3] Univ Calif San Francisco, Dept Urol, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[5] Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[6] Stanford Univ, Dept Urol, Stanford, CA 94305 USA

[7] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V5Z 1M9, Canada

[8] Cleveland Clin, Dept Pathol, Cleveland, OH 44106 USA

[9] Eastern Virginia Med Sch, Dept Pathol, Norfolk, VI USA

[10] Eastern Virginia Med Sch, Dept Microbiol & Mol Cell Biol, Norfolk, VI USA

[11] Eastern Virginia Med Sch, Dept Urol, Norfolk, VI USA

[12] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA

[13] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA

[14] Univ Washington, Dept Urol, Seattle, WA 98195 USA

[15] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[16] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98104 USA

[17] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Biostat & Biomath, Seattle, WA 98104 USA

[18] Univ Washington, Med Ctr, Dept Pathol, Seattle, WA 98195 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2013年 / 20卷 / 01期

关键词：

prostate cancer; prognosis; tissue microarray; quota sampling; RADICAL RETROPUBIC PROSTATECTOMY; BIOCHEMICAL RECURRENCE; MORTALITY; RISK; PROGRESSION; COHORT;

D O I：

10.1097/PAP.0b013e31827b665b

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Tissue microarrays (TMAs) provide unique resources for rapid evaluation and validation of tissue biomarkers. The Canary Foundation Retrospective Prostate Tissue Microarray Resource used a rigorous statistical design, quota sampling, a variation of the case-cohort study, to select patients for inclusion in a multicenter, retrospective prostate cancer TMA cohort. The study is designed to definitively validate tissue biomarkers of prostate cancer recurrence after radical prostatectomy. Tissue samples from over 1000 participants treated for prostate cancer with radical prostatectomy between 1995 and 2004 were selected at 6 participating institutions in the United States and Canada. This design captured the heterogeneity of screening and clinical practices in the contemporary North American population. Standardized clinical data were collected in a centralized database. The project has been informative in several respects. The scale and complexity of assembling TMAs with over 200 cases at each of 6 sites involved unanticipated levels of effort and time. Our statistical design promises to provide a model for outcome-based studies where tissue localization methods are applied to high-density TMAs.

引用

页码：39 / 44

页数：6

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