Probiotics for the prevention and treatment of Clostridium difficile in older patients

被引：10

作者：

Islam, Jasmin ^{[1
]}

Cohen, Jonathan ^{[1
]}

Rajkumar, Chakravarthi ^{[1
]}

Llewelyn, Martin J. ^{[1
]}

机构：

[1] Brighton & Sussex Med Sch, Div Med, Brighton, E Sussex, England

来源：

AGE AND AGEING | 2012年 / 41卷 / 06期

关键词：

probiotics; Clostridium difficile; immunesenescence; antibiotic-associated diarrhoea; intestinal microflora; older people; ANTIBIOTIC-ASSOCIATED DIARRHEA; SACCHAROMYCES-BOULARDII; CONTROLLED-TRIAL; DOUBLE-BLIND; PROPHYLAXIS; VANCOMYCIN; MICROBIOTA; EFFICACY; ANTIBODY;

D O I：

10.1093/ageing/afs077

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Clostridium difficile infection (CDI) is the leading cause of nosocomial diarrhoea in older people, causing substantial morbidity and mortality. The fact that CDI is almost exclusively a disease of older people and the debilitated indicates that patient susceptibility is a major determinant of who gets CDI. It would help efforts to combat this disease if we better understood and could reduce patient susceptibility. In this regard, several strategies are currently under investigation. The use of probiotics for CDI has received particular attention in the medical and lay media. Patients and their carers often ask doctors about them. In this review article, we describe the pathogenesis of CDI before looking at the ageing host in more detail. We discuss how probiotics may work and review the current evidence for their use in CDI.

引用

页码：706 / 711

页数：6

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