Background Preterm birth at very low birth weight (VLBW, < 1500 g) has a multitude of consequences that extend to various aspects of adult life. Little is known about the long-term reproductive outcome of VLBW that survive to adulthood. Aims: To evaluate the reproductive outcome of VLBW infants who survive to adulthood (next-generation). Study design: Retrospective cohort. Subjects: Infants born at a single tertiary center between the years 1982-1997 who survived to 18 years of age (first-generation). Outcome measures: The number and the birth weight of offspring from adults born with VLBW were compared to those of other birth weight groups born in the same epoch: 1500-2499 g, 2500-3799 g (reference group) and 3800 g. We calculated the ratio of actual compared to expected number of children in the next-generation for extreme birth weight parents, using the reference group as a control group and adjusting for birth year. Thereafter, we measured whether first-generation VLBW had an increased risk for a VLBW in the next-generation. Results: After exclusions, we identified first-generation 67,183 births, including 618 (9.2%) VLBW. There were 193 males and 184 female VLBW infants who survived to adulthood. Both female and male first-generation patients from the VLBW group had half the reproductive rate relative for the normal birth weight group. After adjusting for parental age, male and female VLBW survivors had no significant risk for a VLBW neonate in the next-generation, however, the overall number of are small and may limit any conclusion. Conclusion: VLBW children who reach adulthood may be at a significantly lower reproductive capacity.
机构:
Columbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10027 USA
Columbia Univ, Joseph L Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USAColumbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10027 USA
Ananth, Cande V.
Schisterman, Enrique F.
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Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, Bethesda, MD USAColumbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10027 USA
机构:
Univ Hosp Bonn, Dept Neonatol, Bonn, GermanyUniv Warwick, Dept Psychol, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
Bartmann, Peter
Wolke, Dieter
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Univ Warwick, Dept Psychol, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
Univ Warwick, Warwick Med Sch, Div Mental Hlth & Wellbeing, Coventry CV4 7AL, W Midlands, EnglandUniv Warwick, Dept Psychol, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Boeri, Luca
Ventimiglia, Eugenio
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Ventimiglia, Eugenio
Capogrosso, Paolo
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Capogrosso, Paolo
Ippolito, Silvia
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Ippolito, Silvia
Pecoraro, Angela
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Pecoraro, Angela
Paciotti, Marco
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Paciotti, Marco
Scano, Roberta
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Scano, Roberta
Galdini, Alessandro
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IRCCS Osped San Raffaele, Dept Obstet & Gynaecol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Galdini, Alessandro
Valsecchi, Luca
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IRCCS Osped San Raffaele, Dept Obstet & Gynaecol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Valsecchi, Luca
Papaleo, Enrico
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IRCCS Osped San Raffaele, Dept Obstet & Gynaecol, Milan, Italy
IRCCS Osped San Raffaele, Infertil Unit, Unit Obstet Gynecol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Papaleo, Enrico
Montorsi, Francesco
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Montorsi, Francesco
Salonia, Andrea
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
机构:
Columbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USA
Bonanno, Clarissa
Wapner, Ronald J.
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Columbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USA
机构:
Columbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10027 USA
Columbia Univ, Joseph L Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USAColumbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10027 USA
Ananth, Cande V.
Schisterman, Enrique F.
论文数: 0引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, Bethesda, MD USAColumbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10027 USA
机构:
Univ Hosp Bonn, Dept Neonatol, Bonn, GermanyUniv Warwick, Dept Psychol, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
Bartmann, Peter
Wolke, Dieter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Warwick, Dept Psychol, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
Univ Warwick, Warwick Med Sch, Div Mental Hlth & Wellbeing, Coventry CV4 7AL, W Midlands, EnglandUniv Warwick, Dept Psychol, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Boeri, Luca
Ventimiglia, Eugenio
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h-index: 0
机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Ventimiglia, Eugenio
Capogrosso, Paolo
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h-index: 0
机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Capogrosso, Paolo
Ippolito, Silvia
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机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Ippolito, Silvia
Pecoraro, Angela
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Pecoraro, Angela
Paciotti, Marco
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IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Paciotti, Marco
Scano, Roberta
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机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Scano, Roberta
Galdini, Alessandro
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IRCCS Osped San Raffaele, Dept Obstet & Gynaecol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Galdini, Alessandro
Valsecchi, Luca
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机构:
IRCCS Osped San Raffaele, Dept Obstet & Gynaecol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Valsecchi, Luca
Papaleo, Enrico
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h-index: 0
机构:
IRCCS Osped San Raffaele, Dept Obstet & Gynaecol, Milan, Italy
IRCCS Osped San Raffaele, Infertil Unit, Unit Obstet Gynecol, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Papaleo, Enrico
Montorsi, Francesco
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h-index: 0
机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Montorsi, Francesco
Salonia, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
Univ Vita Salute San Raffaele, Milan, ItalyIRCCS Osped San Raffaele, URI, Div Expt Oncol, Unit Urol, Milan, Italy
机构:
Columbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USA
Bonanno, Clarissa
Wapner, Ronald J.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Div Maternal Fetal Med, Dept Obstet & Gynecol, New York, NY 10032 USA